Publication Date:
1996-12-06
Description:
In nematodes, flies, and mammals, dosage compensation equalizes X-chromosome gene expression between the sexes through chromosome-wide regulatory mechanisms that function in one sex to adjust the levels of X-linked transcripts. Here, a dosage compensation complex was identified in the nematode Caenorhabditis elegans that reduces transcript levels from the two X chromosomes in hermaphrodites. This complex contains at least four proteins, including products of the dosage compensation genes dpy-26 and dpy-27. Specific localization of the complex to the hermaphrodite X chromosomes is conferred by XX-specific regulatory genes that coordinately control both sex determination and dosage compensation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chuang, P T -- Lieb, J D -- Meyer, B J -- GM30702/GM/NIGMS NIH HHS/ -- T32 GM07127/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1996 Dec 6;274(5293):1736-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8939870" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Caenorhabditis elegans/*genetics/metabolism
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*Caenorhabditis elegans Proteins
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Carrier Proteins/analysis/chemistry/*metabolism
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Disorders of Sex Development
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*Dosage Compensation, Genetic
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Electrophoresis, Polyacrylamide Gel
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Female
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Genes, Helminth
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Genes, Regulator
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Helminth Proteins/analysis/chemistry/*metabolism
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Male
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Nuclear Proteins/analysis/chemistry/*metabolism
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Precipitin Tests
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RNA, Helminth/metabolism
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RNA, Messenger/metabolism
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Sex Determination Analysis
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X Chromosome/chemistry/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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