Publication Date:
1985-01-04
Description:
The eye lens of the Fraser mouse contains a dominantly inherited cataract with reduced amounts of seven distinct but homologous gamma crystallins encoded by a family of gamma-crystallin genes. The results of experiments with cultured lenses, cell-free RNA translation, and Northern blot hybridization indicated a specific loss of the family of gamma-crystallin messenger RNA's in the Fraser mouse lens. Southern blot hybridization of genomic DNA's from normal and Fraser mice showed no differences in gamma-crystallin coding sequences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garber, A T -- Winkler, C -- Shinohara, T -- King, C R -- Inana, G -- Piatigorsky, J -- Gold, R J -- New York, N.Y. -- Science. 1985 Jan 4;227(4682):74-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3964960" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cataract/*genetics
;
Crystallins/*genetics
;
Genes
;
Lens, Crystalline/metabolism
;
Mice
;
Mice, Mutant Strains
;
Nucleic Acid Hybridization
;
Protein Biosynthesis
;
RNA, Messenger/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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