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  • Male  (34)
  • American Association for the Advancement of Science (AAAS)  (34)
  • 1980-1984  (34)
  • 1982  (34)
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Keywords
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  • American Association for the Advancement of Science (AAAS)  (34)
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  • 1980-1984  (34)
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  • 1
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    Hyperglycemia of diabetic rats decreased by a glucagon receptor antagonist (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-26
    Description: The glucagon analog [l-N alpha-trinitrophenylhistidine, 12-homoarginine]-glucagon (THG) was examined for its ability to lower blood glucose concentrations in rats made diabetic with streptozotocin. In vitro, THG is a potent antagonist of glucagon activation of the hepatic adenylate cyclase assay system. Intravenous bolus injections of THG caused rapid decreases (20 to 35 percent) of short duration in blood glucose. Continuous infusion of low concentrations of the inhibitor led to larger sustained decreases in blood glucose (30 to 65 percent). These studies demonstrate that a glucagon receptor antagonist can substantially reduce blood glucose levels in diabetic animals without addition of exogenous insulin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, D G -- Goebel, C U -- Hruby, V J -- Bregman, M D -- Trivedi, D -- AM21085/AM/NIADDK NIH HHS/ -- AM25318/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Feb 26;215(4536):1115-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6278587" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diabetes Mellitus, Experimental/*drug therapy ; Glucagon/*analogs & derivatives/*antagonists & inhibitors/therapeutic use ; Hyperglycemia/*drug therapy ; Male ; Rats ; Receptors, Cell Surface/*drug effects ; Receptors, Glucagon ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Sex and handedness differences in cerebral blood flow during rest and cognitive activity (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-13
    Description: Cognitive activity resulted in increased flow of blood to the cerebral hemispheres. The increase was greater to the left hemisphere for a verbal task and greater to the right hemisphere for a spatial task. The direction and degree of hemispheric flow asymmetry were influenced by sex and handedness, females having a higher rate of blood flow per unit weight of brain, and females and left-handers having a greater percentage of fast-clearing tissue, presumably gray matter.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gur, R C -- Gur, R E -- Obrist, W D -- Hungerbuhler, J P -- Younkin, D -- Rosen, A D -- Skolnick, B E -- Reivich, M -- MH 30456/MH/NIMH NIH HHS/ -- NS-10939-09/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 13;217(4560):659-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089587" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Brain/metabolism/*physiology ; *Cerebrovascular Circulation ; *Cognition ; Female ; *Functional Laterality ; Humans ; Male ; Metabolic Clearance Rate ; Rest ; *Sex Characteristics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Asian bull elephants: Flehmen-like responses to extractable components in female elephant estrous urine (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-09
    Description: Flehmen-like responses (urine tests) are one of the characteristic behavioral reactions of male Asian elephants (Elephants maximus) to cow elephants in estrus. Components of the urine of estrous cow elephants were extracted with organic solvents and partially purified by chromatography and shown to evoke Flehmen-like responses when they were presented to adult bulls.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rasmussen, L E -- Schmidt, M J -- Henneous, R -- Groves, D -- Daves, G D Jr -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):159-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089549" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Elephants/anatomy & histology/*physiology ; Estrus Detection ; Female ; Male ; Pheromones/*urine ; Sex Attractants/isolation & purification/*urine ; *Sexual Behavior, Animal
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-27
    Description: Leukotriene D4 (2 c 10(-9) mole), injected into the left circumflex coronary artery of anesthetized sheep, produced profound coronary vasoconstriction and impaired regional ventricular wall motion. This cardiac effect was neither inhibited by prior treatment of the sheep with a cyclooxygenase inhibitor nor associated with thromboxane B2 release into the coronary sinus. Intravenous FPL 55712 completely abolished the coronary vasoconstriction of leukotriene D4, but a significant reduction of regional wall shortening persisted.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Michelassi, F -- Landa, L -- Hill, R D -- Lowenstein, E -- Watkins, W D -- Petkau, A J -- Zapol, W M -- HL23591/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):841-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6808665" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Pressure/drug effects ; Chromones/pharmacology ; Coronary Circulation/drug effects ; Coronary Vessels/*drug effects ; Cyclooxygenase Inhibitors ; Female ; Heart Ventricles/drug effects ; Ibuprofen/pharmacology ; Male ; Myocardial Contraction/drug effects ; SRS-A/*pharmacology ; Sheep ; Thromboxane B2/metabolism ; Vasoconstriction/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Sex preselection in mammals? Separation of sperm bearing Y and "O" chromosomes in the vole Microtus oregoni (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-26
    Description: The two sex determining sperm populations of the vole Microtus oregoni were separated according to DNA content by use of flow sorting instrumentation. Although the sperm were not viable, they should be useful for addressing the question of haploid expression of genes linked to sex chromosomes and for efficiently searching for biochemical markers that differentiate the two populations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pinkel, D -- Gledhill, B L -- Lake, S -- Stephenson, D -- Van Dilla, M A -- New York, N.Y. -- Science. 1982 Nov 26;218(4575):904-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6753153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arvicolinae/genetics ; DNA/analysis ; Flow Cytometry/methods ; Fluorescent Dyes ; Male ; Sex Chromosomes/ultrastructure ; *Sex Determination Analysis ; Spermatozoa/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Role of serotonergic input in the regulation of the beta-adrenergic receptor-coupled adenylate cyclase system (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-26
    Description: The action of desipramine on the norepinephrine-sensitive adenylate cyclase system and the density of beta-adrenergic receptors in rat cortex was studied after selective lesioning of serotonergic neurons with 5,7-dihydroxytryptamine. In animals with lesions desipramine failed to reduce the density of beta-adrenoceptors but decreased the response of adenosine 3',5'-monophosphate to isoproterenol and norepinephrine to the same degree as in animals without lesions. The results demonstrate a functional linkage between serotonergic and noradrenergic systems in the rat cortex, with beta-adrenergic receptors and neurohormonal sensitivity of the adenosine 3',5'-monophosphate-generating system being under separate regulatory control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Janowsky, A -- Okada, F -- Manier, D H -- Applegate, C D -- Sulser, F -- Steranka, L R -- New York, N.Y. -- Science. 1982 Nov 26;218(4575):900-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291152" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; Animals ; Cerebral Cortex/*physiology ; Cyclic AMP/biosynthesis ; Desipramine/pharmacology ; Male ; Rats ; Receptors, Adrenergic/*physiology ; Receptors, Adrenergic, beta/*physiology ; Serotonin/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Coronary vascular reactivity after acute myocardial ischemia (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-05
    Description: Exogenous thrombin produced a biphasic response (a potent dose-related vasodilatation followed by vasoconstriction) in nonischemic canine coronary arteries. The vasodilatation was not blocked by propranolol, atropine, or indomethacin, but was completely blocked by heparin or denudation of the intimal endothelial cells. A similar loss of vasodilating response to thrombin occurred in ischemic coronary arteries with a concomitant enhancement of vasoconstriction. This study indicates that altered responses to thrombin in coronary arteries with damaged endothelium may play an important role in the pathogenesis of coronary vasospasm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ku, D D -- HL-24485/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Nov 5;218(4572):576-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123259" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Coronary Circulation/*drug effects ; Coronary Disease/*physiopathology ; Dogs ; Endothelium/drug effects ; Male ; Muscle, Smooth, Vascular/*physiopathology ; Myocardial Infarction/*physiopathology ; Thrombin/*pharmacology ; Vasoconstriction/drug effects ; Vasomotor System/drug effects ; Verapamil/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Scanning electron microscopy with energy-dispersive x-ray spectrometry was used to analyze the elemental content of neurofibrillary tangle (NFT)-bearing and NFT-free neurons within the Sommer's sector (H1 region) of the hippocampus in Guamanian Chamorros with amyotrophic lateral sclerosis and parkinsonism-dementia and in neurologically normal controls. Preliminary data indicate prominent accumulation of aluminum within the nuclear region and perikaryal cytoplasm of NFT-bearing hippocampal neurons, regardless of the underlying neurological diagnosis. These findings further extend the association between intraneuronal aluminum and NFT formation and support the hypothesis that environmental factors are related to the neurodegenerative changes seen in the Chamorro population.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perl, D P -- Gajdusek, D C -- Garruto, R M -- Yanagihara, R T -- Gibbs, C J -- AG-01415/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1053-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112111" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Aluminum/*metabolism ; Amygdala/*pathology ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; Dementia/complications ; Female ; Guam ; Humans ; Hypothalamus/metabolism ; Male ; Middle Aged ; Neurofibrils/metabolism ; Neurons/metabolism ; Parkinson Disease/*metabolism ; Sclerosis ; Spectrometry, X-Ray Emission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Prenatal and neonatal exposure to cimetidine results in gonadal and sexual dysfunction in adult males (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-29
    Description: Exposure of rats to cimetidine during intrauterine life and the immediate neonatal period results in hypoandrogenization in adult life with decreased weights of androgen-dependent tissues and decreased concentrations of testosterone. Moreover, sexual behavior patterns in adult life are disturbed as shown by a lack of sexual motivation and decreased performance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anand, S -- Van Thiel, D H -- New York, N.Y. -- Science. 1982 Oct 29;218(4571):493-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123252" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*etiology ; Animals ; Animals, Suckling ; Cimetidine/metabolism/*toxicity ; Female ; Guanidines/*toxicity ; Male ; Pregnancy ; Pregnancy, Animal/drug effects ; Rats ; Sex Differentiation/*drug effects ; Sexual Behavior, Animal/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Ethanol in low doses augments calcium-mediated mechanisms measured intracellularly in hippocampal neurons (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-15
    Description: The electrophysiological effects of ethanol in low doses (5 to 20 millimoles per liter or 23 to 92 milligrams per 100 milliliters) were examined intracellularly in CA1 cells of rat hippocampus in vitro. Inhibitory and excitatory postsynaptic potentials were increased when ethanol was applied to the respective synaptic terminal regions. Postsynaptically, ethanol caused a moderate hyperpolarization with increased membrane conductance, even when synaptic transmission was blocked. Ethanol augmented the hyperpolarization that followed repetitive firing or that followed the eliciting of calcium spikes in the presence of tetrodotoxin, but not the rapid afterhyperpolarization in calcium-free medium. Ethanol appears to augment calcium-mediated mechanisms both pre- and postsynaptically.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carlen, P L -- Gurevich, N -- Durand, D -- R01 NS16660-01/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 15;215(4530):306-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053581" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/physiology ; Electric Conductivity ; Ethanol/*pharmacology ; Hippocampus/*drug effects/physiology ; Male ; Membrane Potentials/drug effects ; Potassium/physiology ; Rats ; Rats, Inbred Strains ; Synaptic Membranes/drug effects ; Tetrodotoxin/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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