ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Four analogues of LH-RH modified in position 5 have been synthesized using either classical procedures or the solid phase method. The gonadotropin-releasing activities were determined by radioimmunological measurements of LH and FSH in vivo and in vitro and the immunoreactivities by a specific LH-RH radioimmunoassay (RIA). The following relative potencies and immunoractivities were found: Textin vivoin vitroImmuno-reactivityLH-RH:100 %100 %100 %[Tyr(Me)5]-LH-RH:8.6%6.0%40.0%[Phe5]-LH-RH:42.5%27.5%17.0%[Cha5]Abbreviations were used according to [37]; Cha = cyclohexyl-L-alanine.-LH-RH:22.4%27.8%10.0%[Gly5]-LH-RH:0.1%0.5%0.7%
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19740570728
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