ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The constitution of the nonadecapeptide Ro 09-0198 (1) has been established by homonuclear two-dimensional NMR spectroscopy. The peptide contains three sulfide bridges and a bridge formed from the side chain of a lysine residue (lysinoalanine moiety). Only the composition was known before, thus the complete sequencing and the elucidation of the bridges had to be performed. Of special importance was the application of the RELAYED-NOESY experiment. This technique was improved by the introduction of a double-quantum filter to reduce the tailing around the diagonal. The resulting sequence of 1 exhibits a surprizing analogy of this immunopotentiating peptide to the ACE inhibitor ancovenin.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19870700322
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