ISSN:
1432-1211
Keywords:
Key words Fc receptor
;
Polymorphism
;
Autoimmune disorder
;
Infectious disease
;
Leukocyte
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Two groups of receptors for immunoglobulin G (FcγR) can be distinguished. Endothelial cells and placental syncytiotrophoblasts express an MHC class I-like FcγR important for regulation of IgG half-life and IgG transport, respectively. FcγR expressed on leukocytes constitute a heterogeneous family of membrane bound and soluble proteins. The various FcγR (sub) classes of this family differ in ligand affinity and specificity, which is determined by primary structure, glycosylation, association with signaling subunits, and environmental factors (such as serine proteases). The finding that polymorphisms of FcγRIIa, FcγRIIIa, and FcγRIIIb critically affect interaction with antibodies has prompted analysis in patients which provided tantalizing evidence for the relevance of FcγR polymorphisms as risk factors for a number of infectious and autoimmune diseases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002510050426
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