ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Organ engineering remains a challenge to researchers. We tried to reconstruct kidney-like tissueusing tissue engineering technique. Kidney fragments were isolated from rat E16 embryonickidneys and seeded on either ECM gel or on polyglycolic acid (PGA) fibers, then implanted in vivointo the subcutaneous tissue of nude mice for 2 and 3 weeks, respectively. As a negative control,ECM alone was implanted. Results showed that kidney like tissue could be formed in ECMfragmentconstructs after 2 or 3 weeks of implantation, including the formation of glomeruli,tubules and collecting ducts. In addition, these structures seemed more mature in 3 weeksspecimens than that of 2 weeks. Further development of this model may lay a solid foundation forkidney tissue engineering
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.1.pdf
Permalink