ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Nanocomposites consisting of biologically active ions, which can enhance cell viabilityand activate gene expression, are regarded as promising bone regenerative materials. We report anew method for the layer-by-layer (LbL) assembly of biologically active strontium ions in thecore-shell Silica@OCP system for an efficient controlled-release. The strontium ions wereassembled by using a pH-responsive electrostatic interaction to generate three-dimensionalgradients within the silica nanospheres, and then a porous OCP (octacalcium phosphate) shells wascoated on the microunits tailored by polyelectrolyte molecules. This core-shell-like microstructurecan achieve the multicomponents administration and controlled release of essential trace silicon andzinc ions based on the barrier effect of OCP shell and pH-dependent manner, respectively
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1057.pdf
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