Publication Date:
2014-09-20
Description:
Three furoeremophilane-type sesquiterpenoids, including one new, 1 α -acetoxy-6 β -(benzoyloxy)-10 β -hydroxy-9-oxofuroeremophilane ( 1 ), and two known, 1 β ,6 β -diacetoxy-9-oxofuroeremophilane ( 2 ) and (6 α )-furoeremophilan-14,6-olide ( 3 ), were isolated from the root bark of Acanthopanax leucorrhizus from China. Their structures were elucidated on the basis of comprehensive spectroscopic analyses, including IR, HR-ESI-MS, 1D- and 2D-NMR experiments. A preliminary bioassay revealed that compound 1 exhibits weak cytotoxicities against the human tumor cell lines MCF-7 and SMMC-7721 with the IC 50 values of 75.12±1.69 and 168.36±2.01 μg/ml, respectively. Compound 1 and 2 showed moderate activities against Escherichia coli with the MIC values of 32 and 64 μg/ml, respectively.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
Permalink