Publication Date:
2013-10-17
Description:
The first asymmetric total synthesis of (−)-ligustiphenol is reported. The key step was conducted by exploiting a steric hindrance effect to control the formation of the adduct in a nucleophilic α -Li-phenolate addition reaction to the intermediate α -oxo (−)-menthyl ester. The synthesis is concise and feasible for the construction of analogous compounds and investigation of their biological activity.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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