Publication Date:
2012-08-01
Description:
Background: To explore the association of ALOX5AP single nucleotide polymorphisms (SNPs) andhaplotype with the occurrence of cerebral infarction in the Han population of northern China. Methods: Blood samples were collected from 236 patients of Han ancestry with a history of cerebralinfarction and 219 healthy subjects of Han ancestry with no history of cerebral infarction orcardiovascular disease. Applied Biosystems(R) TaqMan(R) SNP Genotyping Assays for SNPgenotyping were used to determine the genotypes of 7 ALOX5AP SNP alleles (rs4073259,rs4769874, rs9315050, rs9551963, rs10507391, rs9579646, and rs4147064). Results: One SNP allele (A) of rs4073259 was significantly associated with development of cerebralinfarction (P = 0.049). In comparison to control groups, haplotype rs9315050&rs9551963AAAC [OR (95 % CI) =1.53 (1.02-2.29)], and genotypes rs4147064 CT [OR (95 % CI)=1.872 (1.082-3.241)], and rs9551963 AC [OR (95 % CI) = 2.015 (1.165-3.484)] increasedthe risk of cerebral infarction in patients with hypertension. Genotype rs9579646 GG [OR (95% CI) = 2.926 (1.18-7.251)] increased the risk of, while rs4073259 GG [OR (95 %CI) = 0.381 (0.157-0.922)] decreased the risk of cerebral infarction in patients with diabetes. Conclusion: These results suggest the ALOX5AP SNP A allele in rs4073259 and genotype rs9579646 GG,rs9551963 AC, and haplotype rs9315050 & rs9551963 AAAC were associated with anincreased risk of ischemic stroke in the Han population, while rs4073259 GG was associatedwith a decreased risk.
Electronic ISSN:
1471-2350
Topics:
Biology
,
Medicine
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