Publication Date:
2015-10-09
Description:
Article Merlin plays a crucial role as a tumour suppressor in liver tumorigenesis. Here, the authors show that a splicing variant of Merlin that lacks exons 2,3 and 4 ( Δ2–4 Merlin) is highly expressed in hepatocarcinoma and promotes tumour metastasis by interfering with the binding of wild-type Merlin to ß-catenin. Nature Communications doi: 10.1038/ncomms9457 Authors: Zai-Li Luo, Shu-Qun Cheng, Jie Shi, Hui-Lu Zhang, Cun-Zhen Zhang, Hai-Yang Chen, Bi-Jun Qiu, Liang Tang, Cong-Li Hu, Hong-Yang Wang, Zhong Li
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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