ISSN:
1432-0703
Source:
Springer Online Journal Archives 1860-2000
Topics:
Energy, Environment Protection, Nuclear Power Engineering
,
Medicine
Notes:
Abstract Transformation products of aminocarb resulting from the selective oxidation of thep-di-methylamino functionality, of them-methyl functionality or from the carbamate N-methyl functionality were synthesized and tested for activity against bovine erythrocyte acetylcholinesterase and for toxicity to house crickets. There was a significant correlation betweenin-vitro inhibition and potencyin-vivo of these products. Although oxidation at thep-dimethylamino group affected toxicity only moderately, oxidation at the other two functional groups led to pronounced decreases in potency. Thus, both assays support the hypothesis that, for aminocarb, environmental oxidation is likely to result in progressive reductions in toxicity of the degrading residues.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01066405
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