Publication Date:
2014-06-21
Description:
Article P2X receptors are ion channels that are controlled by the level of extracellular ATP. Here, Zhao et al. describe the coordinated allosteric changes in two protein domains that couple extracellular ATP-binding to channel gating and show that these changes are essential for the function of the proteins. Nature Communications doi: 10.1038/ncomms5189 Authors: Wen-Shan Zhao, Jin Wang, Xiao-Juan Ma, Yang Yang, Yan Liu, Li-Dong Huang, Ying-Zhe Fan, Xiao-Yang Cheng, Hong-Zhuan Chen, Rui Wang, Ye Yu
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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