ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Osteoporosis is a ‘silent’ disease characterized by thinning cortical bone and disorganizedtrabecular architecture causing bone fragility leading to fracture. Osteoporosis results when the rate of boneresorption far exceeds the rate of bone formation. Current pharmaceutical interventions (estrogen therapy,bisphosphonate-based drugs) focus on inhibiting bone resorption. However, some of these therapies haveserious side effects (e.g., cancer risk from estrogen therapy; osteonecrosis of the jaw and delayed fracturehealing from bisphosphonate-based drugs). The long term objective of the study was to develop a novelmaterial for potential osteoporosis therapy, prevention and fracture repair. This novel material MZF-CaP orsynthetic bone mineral, SBM) incorporates Mg, Zn and F ions in a calcium phosphate matrix. Separately,magnesium (Mg), zinc (Zn) and fluoride (F) ions have been associated with biomineralization andosteoporosis therapy in human and in animals. MZF-CaP or SBM was prepared by a modified hydrolysismethod previously described and characterized using x-ray diffraction, FT-IR spectroscopy, inductivecoupled plasma and dissolution in acidic buffer. Separately, male and female Sprague-Dawley rats wererandomly assigned to the following groups depending on the diet: GA: normal on basic diets; GB: on mineraldeficient diets (md); GC: on md + Mg-CaP; GD: on md + Zn-CaP; GE: md+F-CaP; and GF: md+MZF-CaP.The rats were sacrificed after 3 months and the femur bones separated, cleaned of extraneous soft tissues andstored until needed for analyses. Femur bones were analyzed using microradiography (Faxitron), scanningelectron microscopy (SEM) and microCT. Results: SEM, Faxitron and microCT analyses showed thinningof cortical bone and disorganized trabecular bone architecture for osteoporotic rats on mineral deficient diet(GB) and prevention of bone loss in rats receiving the supplemented diets (GC,GD,GE,GF). Conclusion:These results indicate that the novel material, MZF-CaP or SBM had a potential for osteoporosis therapy andprevention. Studies to demonstrate the use of SBM in reversing (recovering) bone loss are in progress
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/55/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.43.pdf
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