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  • 1
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    Retrograde laminin A confines synapse growth [Neuroscience] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-10-24
    Description: Retrograde signals induced by synaptic activities are derived from postsynaptic cells to potentiate presynaptic properties, such as cytoskeletal dynamics, gene expression, and synaptic growth. However, it is not known whether activity-dependent retrograde signals can also depotentiate synaptic properties. Here we report that laminin A (LanA) functions as a retrograde signal...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Modelling of macrosegregation in direct chill casting considering columnar-to-equiaxed transition using 3-phase Eulerian approach (2015)
    Institute of Physics (IOP)
    Details
    Publication Date: 2015-06-12
    Description: A 3-phase Eulerian approach is used to model the macrosegregation during solidification in direct chill (DC) casting of binary bronze (Cu-Sn). The three phases are the melt, the solidifying columnar dendrites and the equiaxed grains. The thermodynamic information of Cu-Sn is included based on published thermodynamic data, which are coupled with the 3-phase solidification model. The occurrence of columnar-to-equiaxed transition (CET), phase interactions, feeding flow, equiaxed sedimentation and their influence on macrosegregation are considered in the model. The model is applied to a laboratory DC casting process of bronze as a benchmark to demonstrate the model potentials. The simulation results of mixed columnar and equiaxed solidification as well as the formation of macrosegregation are presented. The focus of this work is to analyze and discuss the macrosegregation mechanisms by different flow including feeding flow and crystal sedimentation.
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 3
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    Eicosapentaenoic acid attenuates dexamethasome-induced apoptosis by inducing adaptive autophagy via GPR120 in murine bone marrow-derived mesenchymal stem cells (2016)
    Springer Nature
    Details
    Publication Date: 2016-05-27
    Description: Eicosapentaenoic acid attenuates dexamethasome-induced apoptosis by inducing adaptive autophagy via GPR120 in murine bone marrow-derived mesenchymal stem cells Cell Death and Disease 7, e2235 (May 2016). doi:10.1038/cddis.2016.144 Authors: B Gao, Y-H Han, L Wang, Y-J Lin, Z Sun, W-G Lu, Y-Q Hu, J-Q Li, X-S Lin, B-H Liu, Q Jie, L Yang & Z-J Luo
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 4
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    RNF144A ubiquitinates DNA-PKcs to induce apoptosis [Biochemistry] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-07-02
    Description: Several ring between ring fingers (RBR) -domain proteins, such as Parkin and Parc, have been shown to be E3 ligases involved in important biological processes. Here, we identify a poorly characterized RBR protein, Ring Finger protein 144A (RNF144A), as the first, to our knowledge, mammalian E3 ubiquitin ligase for DNA-PKcs....
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 5
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    Extended life-span and stress resistance in the Drosophila mutant methuselah (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-10-30
    Description: Toward a genetic dissection of the processes involved in aging, a screen for gene mutations that extend life-span in Drosophila melanogaster was performed. The mutant line methuselah (mth) displayed approximately 35 percent increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature, and dietary paraquat, a free-radical generator. The mth gene predicted a protein with homology to several guanosine triphosphate-binding protein-coupled seven-transmembrane domain receptors. Thus, the organism may use signal transduction pathways to modulate stress response and life-span.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, Y J -- Seroude, L -- Benzer, S -- AG12289/AG/NIA NIH HHS/ -- EY09278/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1998 Oct 30;282(5390):943-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9794765" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Animals, Genetically Modified ; Base Sequence ; Cloning, Molecular ; DNA Transposable Elements ; *Drosophila Proteins ; Drosophila melanogaster/*genetics/*physiology ; Female ; Food Deprivation ; GTP-Binding Proteins/chemistry/*genetics/metabolism/physiology ; *Genes, Insect ; Hot Temperature ; Insecticide Resistance ; Longevity/genetics ; Male ; Molecular Sequence Data ; Mutation ; Oxidative Stress ; Paraquat/pharmacology ; Receptors, Cell Surface/chemistry/*genetics/metabolism/physiology ; *Receptors, G-Protein-Coupled ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Rotating Atomic Quantum Gases with Light-Induced Azimuthal Gauge Potentials and the Observation of the Hess-Fairbank Effect (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-12-19
    Description: Author(s): P.-K. Chen, L.-R. Liu, M.-J. Tsai, N.-C. Chiu, Y. Kawaguchi, S.-K. Yip, M.-S. Chang, and Y.-J. Lin We demonstrate synthetic azimuthal gauge potentials for Bose-Einstein condensates from engineering atom-light couplings. The gauge potential is created by adiabatically loading the condensate into the lowest energy Raman-dressed state, achieving a coreless vortex state. The azimuthal gauge potential... [Phys. Rev. Lett. 121, 250401] Published Tue Dec 18, 2018
    Keywords: General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 7
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    Synthetic magnetic fields for ultracold neutral atoms (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-12-04
    Description: Neutral atomic Bose condensates and degenerate Fermi gases have been used to realize important many-body phenomena in their most simple and essential forms, without many of the complexities usually associated with material systems. However, the charge neutrality of these systems presents an apparent limitation-a wide range of intriguing phenomena arise from the Lorentz force for charged particles in a magnetic field, such as the fractional quantum Hall effect in two-dimensional electron systems. The limitation can be circumvented by exploiting the equivalence of the Lorentz force and the Coriolis force to create synthetic magnetic fields in rotating neutral systems. This was demonstrated by the appearance of quantized vortices in pioneering experiments on rotating quantum gases, a hallmark of superfluids or superconductors in a magnetic field. However, because of technical issues limiting the maximum rotation velocity, the metastable nature of the rotating state and the difficulty of applying stable rotating optical lattices, rotational approaches are not able to reach the large fields required for quantum Hall physics. Here we experimentally realize an optically synthesized magnetic field for ultracold neutral atoms, which is evident from the appearance of vortices in our Bose-Einstein condensate. Our approach uses a spatially dependent optical coupling between internal states of the atoms, yielding a Berry's phase sufficient to create large synthetic magnetic fields, and is not subject to the limitations of rotating systems. With a suitable lattice configuration, it should be possible to reach the quantum Hall regime, potentially enabling studies of topological quantum computation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, Y-J -- Compton, R L -- Jimenez-Garcia, K -- Porto, J V -- Spielman, I B -- England -- Nature. 2009 Dec 3;462(7273):628-32. doi: 10.1038/nature08609.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Joint Quantum Institute, National Institute of Standards and Technology, and University of Maryland, Gaithersburg, Maryland, 20899, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19956256" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 8
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    Spin-orbit-coupled Bose-Einstein condensates (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-03-04
    Description: Spin-orbit (SO) coupling--the interaction between a quantum particle's spin and its momentum--is ubiquitous in physical systems. In condensed matter systems, SO coupling is crucial for the spin-Hall effect and topological insulators; it contributes to the electronic properties of materials such as GaAs, and is important for spintronic devices. Quantum many-body systems of ultracold atoms can be precisely controlled experimentally, and would therefore seem to provide an ideal platform on which to study SO coupling. Although an atom's intrinsic SO coupling affects its electronic structure, it does not lead to coupling between the spin and the centre-of-mass motion of the atom. Here, we engineer SO coupling (with equal Rashba and Dresselhaus strengths) in a neutral atomic Bose-Einstein condensate by dressing two atomic spin states with a pair of lasers. Such coupling has not been realized previously for ultracold atomic gases, or indeed any bosonic system. Furthermore, in the presence of the laser coupling, the interactions between the two dressed atomic spin states are modified, driving a quantum phase transition from a spatially spin-mixed state (lasers off) to a phase-separated state (above a critical laser intensity). We develop a many-body theory that provides quantitative agreement with the observed location of the transition. The engineered SO coupling--equally applicable for bosons and fermions--sets the stage for the realization of topological insulators in fermionic neutral atom systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, Y-J -- Jimenez-Garcia, K -- Spielman, I B -- England -- Nature. 2011 Mar 3;471(7336):83-6. doi: 10.1038/nature09887.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Joint Quantum Institute, National Institute of Standards and Technology, University of Maryland, Gaithersburg, Maryland 20899, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21368828" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 9
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    EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-01-30
    Description: Non-small-cell lung cancer is the leading cause of cancer-related death worldwide. Chemotherapies such as the topoisomerase II (TopoII) inhibitor etoposide effectively reduce disease in a minority of patients with this cancer; therefore, alternative drug targets, including epigenetic enzymes, are under consideration for therapeutic intervention. A promising potential epigenetic target is the methyltransferase EZH2, which in the context of the polycomb repressive complex 2 (PRC2) is well known to tri-methylate histone H3 at lysine 27 (H3K27me3) and elicit gene silencing. Here we demonstrate that EZH2 inhibition has differential effects on the TopoII inhibitor response of non-small-cell lung cancers in vitro and in vivo. EGFR and BRG1 mutations are genetic biomarkers that predict enhanced sensitivity to TopoII inhibitor in response to EZH2 inhibition. BRG1 loss-of-function mutant tumours respond to EZH2 inhibition with increased S phase, anaphase bridging, apoptosis and TopoII inhibitor sensitivity. Conversely, EGFR and BRG1 wild-type tumours upregulate BRG1 in response to EZH2 inhibition and ultimately become more resistant to TopoII inhibitor. EGFR gain-of-function mutant tumours are also sensitive to dual EZH2 inhibition and TopoII inhibitor, because of genetic antagonism between EGFR and BRG1. These findings suggest an opportunity for precision medicine in the genetically complex disease of non-small-cell lung cancer.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393352/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393352/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fillmore, Christine M -- Xu, Chunxiao -- Desai, Pooja T -- Berry, Joanne M -- Rowbotham, Samuel P -- Lin, Yi-Jang -- Zhang, Haikuo -- Marquez, Victor E -- Hammerman, Peter S -- Wong, Kwok-Kin -- Kim, Carla F -- CA120964/CA/NCI NIH HHS/ -- CA122794/CA/NCI NIH HHS/ -- CA140594/CA/NCI NIH HHS/ -- CA154303/CA/NCI NIH HHS/ -- CA163896/CA/NCI NIH HHS/ -- CA166480/CA/NCI NIH HHS/ -- K08 CA163677/CA/NCI NIH HHS/ -- R01 CA140594/CA/NCI NIH HHS/ -- R01 CA163896/CA/NCI NIH HHS/ -- R01 CA166480/CA/NCI NIH HHS/ -- R01 HL090136/HL/NHLBI NIH HHS/ -- U01 HL100402/HL/NHLBI NIH HHS/ -- Intramural NIH HHS/ -- England -- Nature. 2015 Apr 9;520(7546):239-42. doi: 10.1038/nature14122. Epub 2015 Jan 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Stem Cell Program, Boston Children's Hospital, Boston, Massachusetts 02115, USA [2] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA [3] Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA. ; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA [2] Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA. ; Stem Cell Program, Boston Children's Hospital, Boston, Massachusetts 02115, USA. ; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. ; Chemical Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA. ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25629630" target="_blank"〉PubMed〈/a〉
    Keywords: Anaphase/drug effects ; Animals ; Antineoplastic Agents, Phytogenic/pharmacology/therapeutic use ; Apoptosis/drug effects ; Carcinoma, Non-Small-Cell Lung/drug therapy/enzymology/genetics/pathology ; Cell Cycle/drug effects ; Cell Line, Tumor ; DNA Helicases/*genetics ; Etoposide/pharmacology/therapeutic use ; Genes, erbB-1/*genetics ; Humans ; Lung Neoplasms/*drug therapy/enzymology/*genetics/pathology ; Mice ; Molecular Targeted Therapy ; Nuclear Proteins/*genetics ; Polycomb Repressive Complex 2/*antagonists & inhibitors ; Topoisomerase II Inhibitors/*pharmacology/*therapeutic use ; Transcription Factors/*genetics ; Xenograft Model Antitumor Assays
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 10
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    Dynamically slowed collapse of a Bose-Einstein condensate with attractive interactions (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-12-04
    Description: Author(s): R. L. Compton, Y.-J. Lin, K. Jiménez-García, J. V. Porto, and I. B. Spielman We rapidly change the scattering length a s of a 87 Rb Bose-Einstein condensate by means of a Feshbach resonance, simultaneously releasing the condensate from its harmonic trapping potential. When a s is changed from positive to negative, the subsequent collapse of the condensate is stabilized by the k... [Phys. Rev. A 86, 063601] Published Mon Dec 03, 2012
    Keywords: Matter waves and collective properties of cold atoms and molecules
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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