ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
There is a clinical and socio-economic need to produce synthetic alternatives toautologous or allogenic bone grafts. Bioactive glasses and glass-ceramics offer great potential in thisarea. The aims of this study were to optimise production of apatite-wollastonite (A-W) glassceramicscaffolds produced by selective laser sintering, in terms of their physical and biologicalproperties and to look at how human Mesenchymal Stem Cells (MSCs) responded to these 3-Dscaffolds in vitro. An indirect selective laser sintering process successfully produced strong, porousscaffolds. Depending upon particle size(s) and infiltration of the porous structure, flexural strengthsbetween 35 MPa and 100 MPa were obtained. Following static seeding of A-W scaffolds withMSCs, fluoresecent actin and nuclei staining, as observed by confocal microscopy, showed thatthese scaffolds supported the adherence of human MSC’s at time periods of up to 21 days. As suchthese seeded scaffolds show great potential for use in bone regenerative medicine
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.923.pdf
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