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  • 1
    Publication Date: 2017-02-27
    Description: Past warm periods provide an opportunity to evaluate climate models under extreme forcing scenarios, in particular high ( 〉  800 ppmv) atmospheric CO2 concentrations. Although a post hoc intercomparison of Eocene ( ∼  50  Ma) climate model simulations and geological data has been carried out previously, models of past high-CO2 periods have never been evaluated in a consistent framework. Here, we present an experimental design for climate model simulations of three warm periods within the early Eocene and the latest Paleocene (the EECO, PETM, and pre-PETM). Together with the CMIP6 pre-industrial control and abrupt 4 ×  CO2 simulations, and additional sensitivity studies, these form the first phase of DeepMIP – the Deep-time Model Intercomparison Project, itself a group within the wider Paleoclimate Modelling Intercomparison Project (PMIP). The experimental design specifies and provides guidance on boundary conditions associated with palaeogeography, greenhouse gases, astronomical configuration, solar constant, land surface processes, and aerosols. Initial conditions, simulation length, and output variables are also specified. Finally, we explain how the geological data sets, which will be used to evaluate the simulations, will be developed.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Format: application/pdf
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  • 2
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    In:  EPIC3Talk presented to the GeoHab steering committee meeting, May 2002. Moss Landing, California USA.
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 3
    ISSN: 1420-9071
    Keywords: Intravenous (parenteral) nutrition ; gastrointestinal tract ; epithelium ; hormones ; glucagon ; enteroglucagon ; gastrin ; PYY ; Cell division ; cell proliferation ; growth control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Intestinal tissue mass was significantly reduced throughout the gastrointestinal tract (p〈0.001) of intravenously fed (TPN) rats. Urogastrone-epidermal growth factor, (URO-EGF), reversed these changes. Although plasma enteroglucagon and gastrin levels showed a small increase with URO-EGF, this was far less than the gut tissue weight change, suggesting that it was unlikely that they were involved in modulating the proliferative response of the intestine to URO-EGF. Peptide tyrosine tyrosine (PYY) levels were however significantly increased by URO-EGF, indicating that PYY may possibly have a role in the modulation of intestinal cell proliferation.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract An investigation of gametogenetic cycles and spawning success in populations of Nephtys caeca and N. hombergi from the River Tyne estuary, North Shields, England, in relation to production of gonadotrophic (GH) and spawning hormones (SH) has been made, based on data collected from 1978–1984. The data show that a consistent pattern of gametogenesis and efficient spawning occurs in populations of N. caeca in north-east England, but that the reproductive cycle of N. hombergi is erratic. Premature oosorption and gametogenic failure in this latter species is associated with a low level of GH production. Following high levels of GH production, gravid females sometimes fail to spawn owing to the non-release of SH. The reproductive energetics and reproductive success of N. caeca and N. hombergi are described in relation to the observed patterns of endocrine activity and the consequent changes in population structure.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract During 1978 and 1979 specimens of Nephtys hombergii in the River Tyne estuary (North East England) became gravid during the winter but did not spawn in the spring breeding season; instead their gametes were resorbed. The drastic effects of these spawning failures were apparent in the population structure in 1980, when the 1978 and 1979 year-classes were shown to be virtually absent, by the size of the individuals in the population and the numbers of growth lines in their jaws. The population structure in 1975, by contrast, indicated that recruitment during the preceding 4 to 5 yr had been good. Spawning was also effective in 1980, and an 0 group was detected in August 1980. Comparable data has been obtained for N. caeca, which occurs in the same beach. It shows that recruitment of this species during 1976–1980 was consistently good, whereas analysis of the age-class frequencies suggests that recruitment of N. caeca was poor in 1973 and 1975. The dominance relationship of the two species in the beach has been reversed during the period 1975–1980. It is suggested that the sympatric distribution of the two species is maintained in part by periodic reproductive failure. The causes of this are not yet known; possible reasons, including the extremely cold conditions experienced in 1978–1979 are discussed. The difference in frequency of the 1978, 1979 and 1980 year classes will now permit a rigorous evaluation of the relationship between the number of growth lines in the jaws and age in N. hombergii.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 16 (1979), S. 73-74 
    ISSN: 1432-1041
    Keywords: cephalexin ; absorption ; elimination ; acutely ill patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 46 (1994), S. 23-28 
    ISSN: 1432-1041
    Keywords: Atenolol ; Captopril ; Central effects ; short term administration ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The central effects of atenolol (50 mg tds) and captopril (50 mg tds) ingested for a period of seven days were studied in ten healthy volunteers. A placebo and two active control drugs, methyldopa (250 mg tds) and oxazepam (10 mg), were included in the design. Oxazepam was ingested on the seventh day only, with a placebo being taken on the preceding six days. On the seventh day, central effects of the drugs were tested at 10.00–11.00 h (session 1), immediately before the subjects' last dose of each drug and at 2.5–3.5 h after the final dose of each drug (1330–1430 h, session 2). Performance was assessed using digit symbol substitution, continuous attention, letter cancellation, choice reaction time, finger tapping, immediate and short-term memory, critical flicker fusion and two flash fusion. Subjects assessed their mood and well-being on a series of 12 visual analogue scales. Recordings of the EEG and body sway were carried out. Neither atenolol nor captopril altered performance at any of the skills tested. There were no effects on subjectively assessed alertness or mood with captopril, while atenolol significantly increased wakefulness in session 2 and when the two sessions were meaned. Similarly, captopril did not modify body sway, while with atenolol there was a significant decrease in activity in the frequency range 1.0–2.75 Hz from session 1 to session 2. Both captopril and atenolol modified the electrical activity of the brain, with captopril increasing delta and theta activity and atenolol reducing delta, alpha and beta activity. Methyldopa significantly increased the number of involuntary rest pauses in the finger tapping task, and the choice reaction time from session 1 to session 2. There was a decrease in passivity during the first session and an increase in wakefulness in session 2 with methyldopa. This drug also decreased body sway in the frequency range 1.0–2.75 Hz activity in session 2, while oxazepam decreased bodys was at 1.0 to 2.75 Hz and increased activity at 2.5–3.0 Hz in session 2. Oxazepam reduced delta, theta and alpha content of the EEG. The present study has been unable to demonstrate any development of adverse central effects with captopril over a period of 7 days of drug ingestion. With atenolol adverse effects were present following short term dosing but were not more pronounced than with acute ingestion seen in previous studies. However effects on the electrical activity of the brain with atenolol remained after 7 days suggesting that the changes reported previously with single ingestions do not disappear.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 561-565 (Oct. 2007), p. 2209-2212 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A holistic model of the atmospheric corrosion of metals is being developed. The modelis based on integrating modules that define such processes as marine aerosol production by oceansand breaking surf, transport of marine aerosols across landscapes, deposition of aerosols ontostructures, cleaning of surfaces by wind and rain, and the wetting and drying of surfaces throughoutsurface temperature and relative humidity cycles. The integration of these modules into a softwareframework enables the user to extract accurate estimates of surface conditions for structures locatedat any geographical location in Australia. Current research is aimed at developing a morefundamental approach to estimating corrosion based on the response of a metal to its environment
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 18 (1980), S. 0 
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: The Tucson, Arizona, metropolitan area has 450,000 inhabitants and is expected to have nearly 800,000 inhabitants by the year 2000. Tucson is totally dependent on ground water drawn from two basin aquifer systems for its water supplies, as are agricultural, mineral and industrial operations in the area.Municipal, agricultural, mineral and industrial ground-water withdrawals in the two basins amount to some 376,000 acre-feet per year (AFY). Dependable ground-water supplies in the two basins amounts to about 80,000 AFY. Thus, the two aquifer systems are overdrafted by approximately 296,000 AFY, 80 percent of which is by irrigation agriculture.In Arizona, ground water belongs to the owner of the land overlying the aquifer. To ensure adequate ground-water supplies, the City of Tucson has been purchasing and retiring farmlands in one of the basins. However, litigation that reached the Arizona Supreme Court led the Court to rule that the City could pump only 2.4 AFY per acre of farmland retired. The City has retired about 12,000 acres in the basin and in 1978 withdrew some 20,000 AFY of ground water for municipal use.Retiring these farmlands to secure water rights impacts on area economy and creates weed problems for farmers who own land near the retired lands. The City of Tucson budgets about $50,000 annually for weed control.A possible alternative to retiring farmlands and to cultivating crops that require heavy irrigation is cultivating arid-adapted vegetation that has economic potential. Jojoba (Simmondsia chinensis) is a shrub native to the Sonoran Desert that appears to be an economically viable arid-land crop. It needs about 1.5 AFY per acre compared with traditional crops grown in the Southwest that have average needs of 4 AFY or more.The economic value of jojoba is based on the oil extracted from its seeds. It is a unique, unsaturated oil composed of nonglyceride esters consisting almost entirely of straight-chain acids and alcohols. Such oils are difficult to synthesize in commercial quantities, and the only known natural source is the sperm whale, an endangered species.If farmers in the basin cultivated jojoba, water use could be reduced by about 2.5 AFY per acre, from 4 AFY per acre for traditional crops to 1.5 AFY for jojoba. Even if the City of Tucson had to subsidize farmers at a rate of $40 per acre for the 10 years it takes jojoba to produce economically feasible yields, the City would save more than 50 percent of the cost to purchase and retire farmlands and still be able to draw water from the basin for municipal uses.This dual use of water in the basin would permit agriculture to continue its contribution to area economy while the City could continue meeting its water needs by piping water out of the basin into the metropolitan area. However, implementing this plan would require changing Arizona ground-water laws.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Physics, Section B 194 (1982), S. 237-250 
    ISSN: 0550-3213
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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