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  • 1
    Electronic Resource
    Electronic Resource
    Crosslinking of double-helical nucleic acids with a photoreactive analog of ethidium (1983)
    s.l. : American Chemical Society
    Biochemistry 22 (1983), S. 3226-3231 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00282a029
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  • 2
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    The U. K. Investment Currency Market (1977)
    Washington : Periodicals Archive Online (PAO)
    International Monetary Fund staff papers. 24:3 (1977:Nov.) 756 
    Details
    ISSN: 0020-8027
    Topics: Economics
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:5171-1977-024-03-000007
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  • 3
    Electronic Resource
    Electronic Resource
    Homologies in the Structures of G-Binding Proteins: An Analysis Based on Elongation Factor EF-TU (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 913-920 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The defining property of G binding proteins is their ability to bind guanine nucleotides, and in this review we shall concentrate upon the domain or subunit responsible for carrying out this function. A common function of such a general nature, exercised in so many different biological organisms ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0989-913
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  • 4
    Electronic Resource
    Electronic Resource
    Models for metal ion function in carbonic anhydrase (1975)
    [s.l.] : Nature Publishing Group
    Nature 258 (1975), S. 677-682 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A model catalyst is described which has properties in common with carbonic anhydrase. The model demonstrates the availability of a mechanism, previously only hypothetical, for the action of the enzyme. It also shows, however, that this mechanism alone is not adequate to produce the high activity of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/258677a0
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  • 5
    Electronic Resource
    Electronic Resource
    A phase II trial of ilmofosine in non-small cell bronchogenic carcinoma (1996)
    Springer
    Investigational new drugs 14 (1996), S. 219-222 
    Details
    ISSN: 1573-0646
    Keywords: ilmofosine ; ether lipids ; non-small cell lung cancer ; phase II trials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have conducted a study of ilmofosine (1-hexadecylthio; 2-methoxyethyl-rac-glycero-3-phosphocho-line) in non-small cell bronchogenic carcinoma, using a schedule of continuous infusion for 5 days and a dose of 300 mg/m2/day. Toxicities were gastrointestinal (nausea, vomiting, diarrhea), fatigue and liver function abnormalities. These were severe and resulted in the removal of some patients from study. No consistent pattern of bone marrow suppression was seen. No tumor regressions occurred in 14 evaluable patients including 5 with no prior therapy. We conclude that ilmofosine is inactive in this tumor at this dose and schedule.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210794
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  • 6
    Electronic Resource
    Electronic Resource
    Phase I study and clinical pharmacology of 6-diazo-5-oxo-L-norleucine (DON) (1985)
    Springer
    Investigational new drugs 3 (1985), S. 369-374 
    Details
    ISSN: 1573-0646
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The toxicity of the glutamine antagonist 6-diazo-5-oxo-L-norleucine (DON) administered as a 24 hour infusion has been evaluated. Studies of the clinical pharmacology of the drug have also been performed in 3 patients. The limiting toxicity of the drug was acute nausea, vomiting and diarrhea that was dose dependent in its severity and duration. The maximum tolerated dose was 600 mg/m2 over 24 hours. The other major toxicity was thrombocytopenia that was maximal 7–10 days after the completion of the infusion. The drug does not exhibit renal, hepatic or central nervous system toxicity. DON achieves steady state levels during these infusions and is eliminated by first order kinetics when the infusion is completed (t1/2α = 1.81 h). The principal route of excretion is renal. A starting dose of 400 mg/m2 would be acceptable for Phase II studies of this drug administered on this schedule.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00170760
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  • 7
    Electronic Resource
    Electronic Resource
    A Phase I trial of spirogermanium administered on a continuous infusion schedule (1984)
    Springer
    Investigational new drugs 2 (1984), S. 305-309 
    Details
    ISSN: 1573-0646
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract We have evaluated the toxicity of the antitumor agent spirogermanium on a schedule of continuous intravenous administration for periods up to five days. The doses tested were between 100 mg/m2/day and 500 mg/m2/day. Peripheral vein phlebitis occurred at all dose levels and was not relieved by addition of hydrocortisone or heparin to the infusion. No phlebitis occurred when the drug was administered through a central vein. The dose limiting toxicity of spirogermanium was neurologic, notably tremors and mental confusion. These problems became progressively more severe at doses above 250 mg/m2/day. There was no discernible bone marrow, renal or hepatic toxicity. One patient developed reversible interstitial pneumonitis. The recommended Phase II dose of spirogermanium is 200 mg/m2/day for five days, with the possibility of escalation in selected patients. Because spirogermanium is more toxic to tumor cells with prolonged exposure than with intermittent exposure, this schedule could be considered for Phase II trials, particularly in diseases thought to be especially sensitive such as ovarian and prostatic carcinoma or lymphomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175381
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  • 8
    Electronic Resource
    Electronic Resource
    Efficacy of tetrahydrocannabinol in patients refractory to standard antiemetic therapy (1988)
    Springer
    Investigational new drugs 6 (1988), S. 243-246 
    Details
    ISSN: 1573-0646
    Keywords: tetrahydrocannabinol ; antiemetic therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Oral delta-9-tetrahydrocannabinol (THC), 15 mg/m2, was compared to prochlorperazine (PCZ), 10 mg. for the control of cancer chemotherapy-related emesis. Thirty-six patients whose vomiting was refractory to standard antiemetic therapy were entered in this randomized comparative cross-over study. THC decreased nausea and vomiting in 23 of 36 (64%) patients compared to 1 of 36 receiving PCZ. THC efficacy was not dependent on the class of antineoplastic-agent inducing the emetic symptoms, age of patients or type of sensorial change experienced. Using the 15 mg/m2 dose, all patients experienced transient sensorial changes, characterized as a pleasant “high” in 19 or a variable state of dysphoria in 17 cases. This study confirms the usefulness of THC in patients whose chemotherapy-induced nausea and vomiting is refractory to other standard antiemetics. While excellent antiemetic control was achieved at the dosage 15 mg/m2, dysphoria was encountered at this dose level and we recommend that an initial dose of 5 mg/m2 which, if necessary, can be carefully increased to achieve maximum antiemetic benefit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175407
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  • 9
    Electronic Resource
    Electronic Resource
    Location of protein S4 on the small ribosomal subunit of E. coli and B. stearothermophilus with protein- and hapten-specific antibodies (1984)
    Springer
    Molecular genetics and genomics 197 (1984), S. 8-18 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In spite of considerable effort there is still serious disagreement in the literature about the question of whether epitopes of ribosomal protein S4 are accessible for antibody binding on the intact small ribosomal subunit. We have attempted to resolve this issue using three independent approaches: (i) a re-investigation of the exposure and the location of epitopes of ribosomal protein S4 on the surface of the 30S subunit and 30S core particles of the E. coli ribosome, including rigorous controls of antibody specificity, (ii) a similar investigation of protein S4 from Bacillus stearothermophilus and (iii) the labelling of residue Cys-31 of E. coli S4 with a fluorescein derivative the accessibility of which towards a fluorescein-specific antibody was demonstrated directly by fluorimetry. In each of the three cases the antigen (E. coli S4, B. stearothermophilus S4 or fluorescein) was found to reside on the small lobe.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327916
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  • 10
    Electronic Resource
    Electronic Resource
    Thermal instability of electrophoresis gels (1987)
    Weinheim : Wiley-Blackwell
    Electrophoresis 8 (1987), S. 339-345 
    Details
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Under certain, defined conditions the temperature-conductivity relationship of electrolytes leads to instabilities in the temperature distribution of electrophoresis gels if these are not efficiently thermostatted. These instabilities manifest themselves in practice in two ways: (i) as unequal temperatures of two identical gels connected in parallel and (ii) as an uneven temperature distribution across the face of individual gels. The latter is a principal cause of the undesirable “smile” effect that occasionally bedevils RNA and DNA sequencing gels. A quantitative description of these instabilities is put forward and suggestions for their avoidance are made.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150080802
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