ISSN:
1574-6968
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
Notes:
Abstract Aspartase, fumarase (Class II) and argininosuccinase are homotetrameric enzymes of native Mr∼ 200 000, and they all catalyse analogous trans-elimination reactions involving fumarate. Amino acid sequence comparisons have revealed five mutually-conserved segments of primary structure, indicating that the enzymes belong to the same family. Several putative active-site residues, e.g., histidine, methionine, lysine, and aspartate or glutamate, have been detected, and one of the highly-conserved segments was also found in an otherwise unrelated homodimeric Class I fumarase.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1574-6968.1988.tb02994.x
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