ISSN:
1420-9071
Keywords:
Amatoxin
;
peptide synthesis
;
structure-activity relationship
;
tool of biological research
;
receptor-mediated endocytosis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Pharmacokinetic studies have provided new insights into humanAmanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far. The main toxin, α-amanitin, is in constant use as a tool in molecular biology and in biological research. First experiments have been reported in which amanitin bound to polymers could be internalized into tumor cells via a receptor-mediated endocytosis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01918382
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