ISSN:
1052-9306
Schlagwort(e):
Chemistry
;
Analytical Chemistry and Spectroscopy
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
The two major metabolites of [14C]niflumic acid, 2-(3′-[14C] trifluoromethylanilino)nicotinic acid have been isolated from human urine. Low and high resolution mass spectrometry indicate that both metabolites (M2a and M2b) are monohydroxylated derivatives of niflumic acid. The 100 MHz proton magnetic resonance spectrum of M2b demonstrates it to be 5-hydroxyniflumic acid, whereas M2a is either the 4′- or 6′-hydroxy derivative. The synthesis of 6′-methoxyniflumic acid methyl ester and comparison of its spectral data and melting point with that of the corresponding derivative of M2a reveal their non-identity. The structure of M2a is, therefore, 4′-hydroxyniflumic acid.
Zusätzliches Material:
4 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/bms.1200010103
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