Publication Date:
2005-11-16
Description:
Alemtuzumab (Campath®, MabCampath®) is a humanized IgG monoclonal antibody targeting the CD52 antigen and is approved for treatment of B-cell chronic lymphocytic leukemia (B-CLL) following treatment with alkylating agents and failing fludarabine treatment. Nonlinear mixed effects modeling was used to characterize the population pharmacokinetics in patients with NHL and CLL after both single dose and multiple dose treatment regimens (n = 118). Model building followed standard procedures. First, an appropriate structural model was identified. Covariate screening was undertaken using generalized additive models to identify those patient characteristics that influenced alemtuzumab pharmacokinetics. Covariates deemed important were then tested using a forward stepwise approach. Only those covariates deemed statistically significant at the 0.05 level were retained in the model. Once the final forward model was identified, the model was reduced using more stringent criteria to remain in the model (P
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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