ISSN:
1434-193X
Keywords:
Sharpless asymmetric dihydroxylation
;
Asimilobin
;
Tetrahydrofuran ring
;
Wittig reactions
;
Annonaceous acetogenins
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
---The most efficient method for the synthesis of the trans/threo/trans-bis(tetrahydrofuran) (THF) ring unit was established, and the first total synthesis of (-)-asimilobin and its diastereomer was then accomplished in twelve and fourteen steps, respectively, from trans-1,5,9-decatriene, by a convergent route with a Wittig reaction as the key step. By virtue of these synthetic results, the absolute configuration of the bis(THF) unit in naturally occurring asimilobin should be corrected.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
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