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  • 1
    Online Resource
    Online Resource
    Coronary Artery Disease: Therapeutics and Drug Discovery (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Cardiology. ; Therapeutics. ; Heart Surgery. ; Pharmacology. ; Cardiology. ; Therapeutics. ; Cardiac Surgery.
    Description / Table of Contents: Coronary Artery Disease: From Mechanism to Clinical Practice -- Evidence in guidelines for treatment of coronary artery disease -- Revascularization For Coronary Artery Disease: Principle And Challenges -- Antithrombotic drugs: pharmacology and perspectives -- Lipid modifying drugs: pharmacology and perspectives -- Anti-hypertensive drugs: pharmacology and perspectives -- Pharmaceutical treatment for Heart failure -- Drug discovery for coronary artery disease.
    Abstract: This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.
    Type of Medium: Online Resource
    Pages: IX, 339 p. 7 illus., 4 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811525179
    Series Statement: Advances in Experimental Medicine and Biology, 1177
    URL: https://doi.org/10.1007/978-981-15-2517-9
    DOI: 10.1007/978-981-15-2517-9
    DDC: 615
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of Modes in the Nanowire Cavity by FDTD Simulation (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 121-123 (Mar. 2007), p. 1125-1128 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: The mode frequency and the quality factor of nanowire cavities are calculated from theintensity spectrum obtained by the finite-difference time-domain (FDTD) technique and the Padéapproximation. In the free-standing nanowire cavity with the dielectric constant 6.0 and the lengthof 5 μm, the quality factors of 130, 159, and 151 are obtained for HE11 with frequency around 798THz, at the cavity radius of 60nm, 75nm, and 90nm, respectively. The Q-factor of 78 is alsocalculated in the nanowire with length of 5 μm and radius of 60nm grown on the sapphire substratewith refractive index 1.8. The obtained mode field distribution of the fundamental transverse modeshows that the mode field confined very well by the nanowire cavity even when the radius ofnanowire is much smaller than the mode wavelength
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/23/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.121-123.1125.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Crystallization and preliminary X-ray analyses of insect neurotoxins with analgesic effect from the scorpion Buthus martensii Karsch (2000)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 56 (2000), S. 1012-1014 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Three insect neurotoxins from the scorpion Buthus martensii Karsch, named BmK I1, BmK I4 and BmK I6, have been purified and crystallized. BmK I1 and BmK I4 show strong toxicity to insects, while BmK I6 is relatively weaker. They all exhibit an evident analgesic effect on mice; this is a novel biological function for scorpion insect toxins. Their crystals diffract to at least 3.5 (BmK I1), 2.8 (BmK I4), 2.8 (BmK I6 crystal form I) and 2.2 Å (of BmK I6 crystal form II) resolution on an ordinary X-ray source. Crystals of BmK I1 belong to space group P6, with unit-cell parameters a = b = 66.2, c = 176.7 Å. BmK I4 crystallized in the tetragonal space group I4, with unit-cell parameters a = b = 134.5, c = 60.6 Å. BmK I6 has been crystallized in two forms: form I belongs to space group C2, with unit-cell parameters a = 46.5, b = 85.2, c = 32.6 Å, β = 110.5°; form II belongs to space group R3, with the hexagonal unit-cell parameters a = b = 44.5, c = 164.7 Å.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444900006004
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  • 4
    Electronic Resource
    Electronic Resource
    Crystallization and preliminary X-ray analysis of a depressant insect toxin from the scorpion Buthus martensii Karsch (2001)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 57 (2001), S. 1313-1315 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Depressant insect toxins are a distinct group of scorpion neurotoxins for which no three-dimensional structures are yet available. A depressant insect toxin named BmK dITAP3 from the scorpion Buthus martensii Karsch (BmK) has been purified and crystallized. Single crystals of dITAP3 grew in the presence of the detergent CYMAL-6 using the hanging-drop vapour-diffusion method with ammonium sulfate as precipitant. A set of diffraction data to 2.6 Å resolution has been collected. Preliminary analysis of the diffraction data indicated that the crystal belonged to space group R3, with unit-cell parameters a = b = 73.29, c = 68.90 Å, α = β = 90, γ = 120°. Assuming two molecules in the asymmetric unit, the estimated solvent content is 53.4%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444901011210
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  • 5
    Electronic Resource
    Electronic Resource
    Structure of a new neurotoxin from the scorpion Buthus martensii Karsch at 1.76 Å (2000)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 56 (2000), S. 25-33 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: A new neurotoxin BmK M2, toxic to both mammals and insects, with the strongest toxicity in the BmK toxin series, has been purified from the Chinese scorpion Buthus martensii Karsch and crystallized with MPD at pH 7.5. The crystals are orthorhombic, belonging to space group P212121, with unit-cell parameters a = 36.64, b = 36.95, c = 37.23 Å. The structure was solved by molecular replacement and refined to R = 0.186 for all reflections to a resolution of 1.76 Å. The whole sequence (64 residues) of BmK M2 was determined by crystallographic analysis based on high-resolution data and the homologous model of BmK M8. The refined BmK M2 structure shows a non-proline cis peptide bond between Pro9 and His10 which enables the C-terminal segment to adopt a conformation different to that of the weak toxin BmK M8. Recently, a mutation analysis had suggested that both the tenth residue and the C-terminus play key roles in receptor binding. Therefore, these features may be related to the binding selectivity of the group III α-like toxins. The charge changes of residues 8, 10, 18, 28, 55 and 59 from neutral or negative to positive or neutral, which leads to a positive electrostatic potential surface, may be responsible for the high toxicity of BmK M2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444999014614
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  • 6
    Electronic Resource
    Electronic Resource
    A series of bioactivity-variant neurotoxins from scorpion Buthus martensii Karsch: purification, crystallization and crystallographic analysis (1999)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 55 (1999), S. 341-344 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Three bioactivity-variant neurotoxins, BmK M1, M4 and M8, have been purified from Chinese scorpion BmK venom. They possess distinct toxic activities against mice in vivo. These proteins also have different electrostatic properties. The relative toxicities for BmK M1, M4 and M8 are 13.3:2.5:1 which, surprisingly, correspond to their respective pI values ranging from basic to acidic 9.01, 7.53 and 5.30, respectively. They have been crystallized in different crystal forms as orthorhombic, hexagonal and monoclinic, respectively. These crystals can diffract to 1.2 (BmK M1), 1.3 (BmK M4) and 1.8 Å (BmK M8) resolution and have been used in data collection. These toxins produced by natural mutagenesis or gene divergence should represent functionally distinct states, thereby forming a valuable system for studying structure–function relationships. The unusual relatively acidic component that first appeared in this series also provides a new concept for a more comprehensive understanding of scorpion neurotoxins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444998006593
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  • 7
    Electronic Resource
    Electronic Resource
    Biodesulfurization of dibenzothiophene and other organic sulfur compounds by a newly isolated Microbacterium strain ZD-M2 (2005)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 247 (2005), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: A new bacterial strain capable of selectively desulfurizing dibenzothiphene (DBT) was isolated from sludge. This organism, designated ZD-M2, clustered most closely with members of the genus Microbacterium, as determined by 16S rRNA gene sequence analysis. Metabolites produced by DBT desulfurization were identified by GC-MS, and two sulfur-free products, 2-methoxybiphenyl (2-MBP) and biphenyl, were detected in addition to 2-hydroxybiphenyl (2-HBP). This strain can also totally degrade 4,6-dimethyl-DBT, thiophene, benzothiophene and 70% diphenylsulfide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/j.femsle.2005.04.025
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  • 8
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    Phyllosomata associated with large gelatinous zooplankton: hitching rides and stealing bites (2014)
    In:  EPIC3ICES Journal of Marine Science: Journal du Conseil, 72(suppl), pp. i124-i127, ISSN: 1054-3139
    Details
    Publication Date: 2017-01-20
    Description: During a zooplankton survey 350 km off the coast of Western Australia, we captured a large and robust zooid of a salp (Thetys vagina), to which six late stage larvae (phyllosomata) of the western rock lobster (Panulirus cygnus) were attached. High-throughput sequencing analyses of DNA extracts from midgut glands of the larvae confirmed that each phyllosoma had consumed mainly salp tissue ( x 1⁄4 64.5% + 15.9 of DNA reads). These results resolve long-standing conjecture whether spiny lobster phyllosomata attach to large gelatinous hosts to feed on them.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 9
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    Condition of larvae of western rock lobster (Panulirus cygnus) in cyclonic and anticyclonic eddies of the Leeuwin Current off Western Australia (2015)
    In:  EPIC3Marine and Freshwater Research, 66(12), pp. 1158, ISSN: 1323-1650
    Details
    Publication Date: 2017-01-20
    Description: Changes in the offshore oceanographic processes are suspected to be the cause of a recent dramatic decline in the settlement of post-larvae of the Western Australian spiny lobster (Panulirus cygnus), which has greatly reduced the productivity from the world’s second-largest spiny lobster fishery. The present study assessed whether there are differences in the nutritional condition of the larvae of P. cygnus sampled from two pairs of cyclonic eddies (CEs) and anticyclonic eddies (AEs). Morphometric and biochemical analyses were undertaken on the mid–late-stage larvae (VI, VII, VIII) sampled offshore from two pairs of adjacent counter-rotating mesoscale eddies in the Leeuwin Current off Western Australia. The results showed that larvae captured from CEs had greater average total dry mass (P , 0.001) than those from AEs. Stage VIII larvae from CEs contained more protein (P , 0.008) (38.5% ` 5.4 s.e.) and lipid (P , 0.005) (67.2% ` 12.1) than did those from AEs. The possible causes for these differences are uncertain but may be related to differences in water temperatures in CEs v. AEs influencing the ability of phyllosomas to accumulate nutritional reserves.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 10
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    Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-06-08
    Description: The correlations between intramyocellular lipid (IMCL), decreased fatty acid oxidation (FAO), and insulin resistance have led to the hypothesis that impaired FAO causes accumulation of lipotoxic intermediates that inhibit muscle insulin signaling. Using a skeletal muscle-specific carnitine palmitoyltransferase-1 KO model, we show that prolonged and severe mitochondrial FAO inhibition results in increased carbohydrate utilization, along with reduced physical activity; increased circulating nonesterified fatty acids; and increased IMCLs, diacylglycerols, and ceramides. Perhaps more importantly, inhibition of mitochondrial FAO also initiates a local, adaptive response in muscle that invokes mitochondrial biogenesis, compensatory peroxisomal fat oxidation, and amino acid catabolism. Loss of its major fuel source (lipid) induces an energy deprivation response in muscle coordinated by signaling through AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) to maintain energy supply for locomotion and survival. At the whole-body level, these adaptations result in resistance to obesity.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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