ISSN:
1476-4687
Source:
Nature Archives 1869 - 2009
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
Notes:
[Auszug] Transforming growth factor-β (TGF-β) potently inhibits cell cycle progression at the G1 phase. Smad3 has a key function in mediating the TGF-β growth-inhibitory response. Here we show that Smad3 is a major physiological substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. ...
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1038/nature02650
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