Publication Date:
2013-11-16
Description:
Bacterial invasion of host tissues triggers polymorphonuclear leukocytes to release DNA [neutrophil extracellular traps (NETs)], thereby immobilizing microbes for subsequent clearance by innate defenses including macrophage phagocytosis. We report here that Staphylococcus aureus escapes these defenses by converting NETs to deoxyadenosine, which triggers the caspase-3-mediated death of immune cells. Conversion of NETs to deoxyadenosine requires two enzymes, nuclease and adenosine synthase, that are secreted by S. aureus and are necessary for the exclusion of macrophages from staphylococcal abscesses. Thus, the pathogenesis of S. aureus infections has evolved to anticipate host defenses and to repurpose them for the destruction of the immune system.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026193/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026193/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thammavongsa, Vilasack -- Missiakas, Dominique M -- Schneewind, Olaf -- AI038897/AI/NIAID NIH HHS/ -- AI052474/AI/NIAID NIH HHS/ -- AI057153/AI/NIAID NIH HHS/ -- R01 AI038897/AI/NIAID NIH HHS/ -- R01 AI052474/AI/NIAID NIH HHS/ -- T32 AI007090/AI/NIAID NIH HHS/ -- U54 AI057153/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2013 Nov 15;342(6160):863-6. doi: 10.1126/science.1242255.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24233725" target="_blank"〉PubMed〈/a〉
Keywords:
Abscess/immunology/microbiology
;
Animals
;
Apoptosis/*immunology
;
Cells, Cultured
;
Cytotoxicity, Immunologic
;
Deoxyadenosines/*metabolism
;
Deoxyribonucleases/metabolism
;
Host-Pathogen Interactions/*immunology
;
Humans
;
Macrophages/immunology/microbiology
;
Mice, Inbred BALB C
;
Neutrophils/*immunology/*microbiology
;
Staphylococcal Infections/*immunology
;
Staphylococcus aureus/enzymology/*pathogenicity
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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