Publication Date:
1999-02-05
Description:
Clinical evidence suggests that cellular immunity is involved in controlling human immunodeficiency virus-1 (HIV-1) replication. An animal model of acquired immune deficiency syndrome (AIDS), the simian immunodeficiency virus (SIV)-infected rhesus monkey, was used to show that virus replication is not controlled in monkeys depleted of CD8+ lymphocytes during primary SIV infection. Eliminating CD8+ lymphocytes from monkeys during chronic SIV infection resulted in a rapid and marked increase in viremia that was again suppressed coincident with the reappearance of SIV-specific CD8+ T cells. These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmitz, J E -- Kuroda, M J -- Santra, S -- Sasseville, V G -- Simon, M A -- Lifton, M A -- Racz, P -- Tenner-Racz, K -- Dalesandro, M -- Scallon, B J -- Ghrayeb, J -- Forman, M A -- Montefiori, D C -- Rieber, E P -- Letvin, N L -- Reimann, K A -- P51 RR000168/RR/NCRR NIH HHS/ -- RR-00168/RR/NCRR NIH HHS/ -- RR-13150/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1999 Feb 5;283(5403):857-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. jschmitz@caregroup.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9933172" target="_blank"〉PubMed〈/a〉
Keywords:
Acquired Immunodeficiency Syndrome/immunology/virology
;
Animals
;
Antibodies, Monoclonal/immunology
;
Antibodies, Viral/blood
;
CD8-Positive T-Lymphocytes/*immunology
;
Disease Progression
;
Gene Products, gag/blood
;
Humans
;
Lymphocyte Count
;
Lymphocyte Depletion
;
Macaca mulatta
;
Neutralization Tests
;
RNA, Viral/blood
;
Simian Acquired Immunodeficiency Syndrome/*immunology/*virology
;
Simian Immunodeficiency Virus/*immunology/physiology
;
T-Lymphocytes, Cytotoxic/immunology
;
Time Factors
;
Viral Load
;
Viremia/immunology/virology
;
Virus Replication
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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