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  • 1
    Electronic Resource
    Electronic Resource
    Group-wise growth of Streptomyces in a medium containing streptomycin (1957)
    Springer
    Archives of microbiology 27 (1957), S. 281-287 
    Details
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have described the observation that Streptomyces griseus colonies grow group-wise on agar media containing streptomycin. We have found that this phenomenon is due to a substance (s) produced by germinating Str. griseus spores in media containing streptomycin, and this substance made the neighbouring spores more tolerant to increasing streptomycin concentrations. The substance is produced specifically by Str. griseus strains. The substance has probably a great molecular size, is thermolabile, not a nucleic acid and the applied enzymes did not inactivate it. Some investigated enzyme-poisons did not influence either its production or its effect on Str. griseus spores. We succeeded in carrying over the substance into liquid phase and separate it from the producing culture and this enables us to furterh purification and investigation of the substance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00409528
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  • 2
    Electronic Resource
    Electronic Resource
    Comparison of Str. griseus strains which produce streptomycin and those which do not (1961)
    Springer
    Archives of microbiology 40 (1961), S. 261-274 
    Details
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Sreptomyces griseus strains which produce streptomycin and which do not were compared by their cultural-physiological behaviour, their capacity of utilizing citrate, micromorphology and phage sensitivity. No correlation is found between any of the examined characteristics and capacity to produce streptomycin. There is one common characteristic among all three strains which do not produce streptomycin i. e., they have a short life cycle in submerged culture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00540578
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  • 3
    Electronic Resource
    Electronic Resource
    Correlation between the physiological state of bacteria and the radioprotective effectiveness of cysteine (1968)
    Springer
    Archives of microbiology 61 (1968), S. 327-334 
    Details
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary E. coli 15 T - cells were cultured in the presence of cysteine, then removed and subjected to X-ray irradiation in cysteine-free buffer. The radiation-sensitivity was then found to decrease in inverse ratio to the concentration of cysteine used. This phenomenon occurred only with log-phase cells, while the radiosensitivity of stat-phase bacteria remained unchanged. The biochemical background of this phenomenon was also studied by means of 35S-Cysteine. The extent and distribution of cysteine incorporation into the fractions of log-phase cells were found to differ from those occurring in the fractions of statphase cells. The biochemical radioprotective effect of cysteine described above suggests two different explanations: a) the radioresistance induced by cysteine presupposes an active metabolic state of the cells, which may correlate with the induction of the repair systems; b) the cysteine incorporated by the cells provides a radio-protective effect; hence only the radiosensitivity of log-phase cells decreases, while that of the stationary phase cells remains unchanged owing to their inability to incorporate cysteine in an amount rendering them effective radioprotectors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00409669
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  • 4
    Electronic Resource
    Electronic Resource
    The effect on escherichia coli B of “radioprotectors” produced by fermentation (1962)
    Springer
    Archives of microbiology 44 (1962), S. 228-232 
    Details
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. The radioprotective activity of several hundreds of fermentation liquids have been examined by methods described in our previous reports. 2. Out of the tested fermentation liquids, good protective ability was rendered—mainly after acid hydrolysis—by the fermentation liquid of Penicillium notatum strain which is applied also in industry. 3. The agent, when it was produced, proved to be d-Penicillamine. 4. The radioprotective activity of d-Penicillamine as well as its ability to reduce the toxicity of nitrogen mustard have been compared with the effect of other wellknown radioprotectors, on an equimolar basis. 5. It was found that its protective ability for E. coli B against both X-ray and nitrogen mustard is about the same degree as that of cysteine. 6. From the results, theoretical and practical conclusions have been drawn.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00510942
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  • 5
    Electronic Resource
    Electronic Resource
    Screening-Methode zum Nachweis der Strahlenschutzwirkung von Streptomyces-Fermentsäften (1961)
    Springer
    Archives of microbiology 40 (1961), S. 119-125 
    Details
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Zusammenfassung 1. Zum Nachweis von biologischen radioprotektiven Substanzen wurde eine mikrobiologische Screening-Methode ausgearbeitet. 2. Bei diesen Untersuchungen wurden Escherichia coli 0 111 und Streptomyces bikiniensis als Testorganismen verwendet. 3. Die Empfindlichkeit des Tests wurde mit Dosen von 1, 10, 100 μg der bekannten Radioprotektoren kontrolliert. 4. Unter den in äquimolaren Dosen verglichenen Protektoren erwiesen sich die SH-Stoffe an beiden Mikroorganismen am wirksamsten. 5. Unter 40 unbekannten Streptomyces-Fermentsäften fanden wir zwei wirksame.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410002
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  • 6
    Electronic Resource
    Electronic Resource
    Ultra-violet /Absorption Spectra of Simple Aliphatic Guanidines (1962)
    [s.l.] : Nature Publishing Group
    Nature 196 (1962), S. 376-377 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Recently, on examining the infra-red and ultraviolet spectra of primycin3, an antituberculotic antibiotic of Sakaguchi-positive nature, the presence of the azomethine group was shown by the ultra-violet maxima at 205-210 mμ, of the basic chromogenes. We pointed out also the effect of the applied ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/196376a0
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  • 7
    Electronic Resource
    Electronic Resource
    Primycin, a New Antibiotic (1954)
    [s.l.] : Nature Publishing Group
    Nature 174 (1954), S. 1105-1106 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The growth of Staph. aureus D. in a medium containing 5 ml. casein hydrolysate is inhibited by 0-01-0-03 ml. of the samples taken from surface cultures six to eight days old, diluted 1 to 10. Submerged cultures give an average yield somewhat below this level. On acidifying the filtrate of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1741105b0
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  • 8
    Electronic Resource
    Electronic Resource
    Infra-Red and Ultra-Violet Spectra of Primycin (1962)
    [s.l.] : Nature Publishing Group
    Nature 193 (1962), S. 243-245 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] RECENTLY, we reported1 on primycin (C19H37O7N)w, an antibiotic of strong anti-tuberculotic effect (0-02 pigm./ml.) which has been determined, similarly to other guanidine antibiotics, with JV-bromosuccinimide, by the modified Sakaguchi colour reaction. Although in the field of nitrogen-bearing ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/193243a0
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  • 9
    Electronic Resource
    Electronic Resource
    Identification of Primycin and Other Guanidino Antibiotics (1964)
    [s.l.] : Nature Publishing Group
    Nature 201 (1964), S. 81-82 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Although it is possible to classify antibiotics orientally into groups with the aid of paper chromatography3,4, the characterization of differences due to their finer chemical structure is, in the case of guanidino antibiotics, a more difficult task. The investigations made by us were : (1) punched ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/201081a0
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  • 10
    Electronic Resource
    Electronic Resource
    Comaprison of Strains of Streptomyces griseus which produce Streptomycin and those which do not (1960)
    [s.l.] : Nature Publishing Group
    Nature 188 (1960), S. 428-428 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] After cultivation in media proposed by Waksman4 they behaved as different species. Comparing our strains on various sources of carbon, they proved to have different characteristics. They all grew on 1 per cent maltose, dextrose, pectin, amylum soluble, glycogen, d-ribose, xylose, d-fructose, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/188428a0
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