Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
International journal of immunogenetics
3 (1976), S. 0
ISSN:
1744-313X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
Sequence data show that the immunoglobulins evolved from two sets of paralogous genes: a gene set coding for the V regions and another for the different C regions.A comparison of sequences from these two gene sets shows homology between the V and C sets of genes: this homology is only significant when VH is compared with Cμ1, Cμ2 and Cγ1. There is a close agreement between our data drawn from sequence comparisons and the data of Poljak et al. (1974) drawn from crystallographic data.This finding is in agreement with the results of the phylogenetic trees of the C and V gene sets: they suggest that the VH subgroups and the first constant domain of the heavy chains are the most ancient. Moreover homology between the red blood cell glycophorin and Cμ2 suggests that immunoglobulins could have a common origin with some membrane proteins.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1744-313X.1976.tb00551.x
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