ISSN:
1573-904X
Keywords:
coating drum
;
tablet motion
;
computer simulation
;
surface time
;
circulation time
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Purpose. The purpose is to develop a new method of finding optimal conditions in tablet coating operations with the use of computer simulation. Methods. DEM(Discrete Element Method), which calculates trajectories of individual tablets by numerically integrating Newton's equations of motion, was used in this simulation. Results. The effects of tablet size, tablet loading, rotation speed on mean surface time, circulation time, and surface time deviation agree qualitatively with experimental results by other workers. Conclusions. It is found that DEM is a useful method of predicting tablet motion in a coating drum.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1016201102355
Permalink