ISSN:
1432-0827
Keywords:
Fluoride
;
Plasma calcium
;
Solubility of bone mineral
;
Mineralization
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
,
Physics
Notes:
Summary In a liquid (22°C) saturated with and in contact with powdered bone apatite, the fluoride ion activity was adjusted to 1–10 parts/106. Due to the fluorapatite (FAP) supersaturation produced hereby, a rapid formation of this salt occurred leading to a decrease of the concentration of the ions involved. When no more fluoride was available in the liquid, the concentrations of calcium and phosphate increased again, due to dissolution of presumeably hydroxyapatite (HAP). Fifty four rats were given either 10, 20, or 40 mg NaF per kg body weight intraperitoneally. The animals were sacrificed from 5 min to 96 h after the injection. The fluoride concentration in plasma increased to a peak, after which it decreased. Plasma calcium decreased and remained low until the fluoride had attained normal levels. The intensity of mineralization of the growing dental hard tissue was monitored on microradiographs. Corresponding to the plasma fluoride peak and the decrease of plasma calcium, a hypermineralized layer was formed while a hypomineralized zone was formed during plasma calcium increase after disappearance of fluoride. Similarities and dissimilarities between thein vitro and thein vivo experiments are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02405391
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