ISSN:
1052-9306
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Some organophosphorous compounds, especially tri-o-cresylphosphate (TOCP), induce delay neuropathy. The cyclic saligenin phosphate (PSP) has been suggested to be the active metabolite of the protoxicant TOCP. The o-isopropylated triphenyl phosphates have been proven not to be neurotoxic. Studying the metabolism of these compounds we found the following cyclic metabolites: 2-phenyl-4H-4,4-dimethyl-1,1,3,2-benzodioxaphosphoran-2-oxide and 2-(o-isopropylphenyl)-4H-4,4-dimethyl-1,1,3,2-benzodioxaphosphoan-2-oxide. Additionally, monohydroxylated metabolites of the parent esters were detectable. The effect of glucuronidation on the formation of the cyclic metabolites is discussed in this paper.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bms.1200190909
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