ISSN:
1432-1041
Keywords:
Fluorophenindione
;
vitamin K antagonist
;
pharmacokinetics
;
loading dose
;
anticoagulant
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary After administration of a single loading dose (80 mg p.o.) of fluorophenindione, the prothrombin level decreased to 37 % in 24 h, and the effect lasted for 48 h. Accordingly, fluorophenindione can be classified as an anticoagulant with an “intermediate” effect. Its elimination half-life was 31 h, which is longer than that of phenindione, because of the greater stability of the fluorinated derivate.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00567127
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