Publication Date:
2005-05-21
Description:
Previous evidence suggested that transfer RNAs (tRNAs) cross the nuclear envelope to the cytosol only once after maturing in the nucleus. We now present evidence for nuclear import of tRNAs in yeast. Several export mutants accumulate mature tRNAs in the nucleus even in the absence of transcription. Import requires energy but not the Ran cycle. These results indicate that tRNAs shuttle between the nucleus and cytosol.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takano, Akira -- Endo, Toshiya -- Yoshihisa, Tohru -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):140-2. Epub 2005 May 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Graduate School of Science, Japan Science and Technology Corporation, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15905365" target="_blank"〉PubMed〈/a〉
Keywords:
Active Transport, Cell Nucleus
;
Adenosine Triphosphate/metabolism
;
Cell Nucleus/genetics/*metabolism
;
Cytosol/*metabolism
;
Introns
;
Mutation
;
RNA Precursors/metabolism
;
RNA, Fungal/*metabolism
;
RNA, Transfer/genetics/*metabolism
;
RNA, Transfer, Amino Acid-Specific/*metabolism
;
RNA, Transfer, Amino Acyl/metabolism
;
RNA, Transfer, Ile/metabolism
;
RNA, Transfer, Pro/metabolism
;
RNA, Transfer, Tyr/metabolism
;
Saccharomyces cerevisiae/genetics/growth & development/*metabolism
;
Transcription, Genetic
;
ran GTP-Binding Protein/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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