Publication Date:
2007-01-20
Description:
A hallmark of epithelial invagination is the constriction of cells on their apical sides. During Drosophila gastrulation, apical constrictions under the control of the transcription factor Twist lead to the invagination of the mesoderm. Twist-controlled G protein signaling is involved in mediating the invagination but is not sufficient to account for the full activity of Twist. We identified a Twist target, the transmembrane protein T48, which acts in conjunction with G protein signaling to orchestrate shape changes. Together with G protein signaling, T48 recruits adherens junctions and the cytoskeletal regulator RhoGEF2 to the sites of apical constriction, ensuring rapid and intense changes in cell shape.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolsch, Verena -- Seher, Thomas -- Fernandez-Ballester, Gregorio J -- Serrano, Luis -- Leptin, Maria -- New York, N.Y. -- Science. 2007 Jan 19;315(5810):384-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17234948" target="_blank"〉PubMed〈/a〉
Keywords:
Adherens Junctions/*physiology/ultrastructure
;
Amino Acid Motifs
;
Animals
;
Armadillo Domain Proteins/metabolism
;
Cell Membrane/metabolism
;
Cell Shape
;
Drosophila Proteins/*metabolism
;
Drosophila melanogaster/*embryology/metabolism
;
Embryo, Nonmammalian/cytology/*physiology/ultrastructure
;
Embryonic Development
;
Gastrula/physiology
;
Heterotrimeric GTP-Binding Proteins/metabolism
;
Membrane Proteins/*metabolism
;
Models, Biological
;
Signal Transduction
;
Transcription Factors/metabolism
;
Twist Transcription Factor/metabolism
;
rho GTP-Binding Proteins/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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