Publication Date:
2004-07-03
Description:
The hippocampus is crucial for spatial memory formation, yet it does not store long-lasting memories. By combining functional brain imaging and region-specific neuronal inactivation in mice, we identified prefrontal and anterior cingulate cortices as critical for storage and retrieval of remote spatial memories [correction]. Imaging of activity-dependent genes also revealed an involvement of parietal and retrosplenial cortices during consolidation of remote memory. Long-term memory storage within some of these neocortical regions was accompanied by structural changes including synaptogenesis and laminar reorganization, concomitant with a functional disengagement of the hippocampus and posterior cingulate cortex [correction]. Thus, consolidation of spatial memory requires a time-dependent hippocampal-cortical dialogue, ultimately enabling widespread cortical networks to mediate effortful recall and use of cortically stored remote memories independently.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maviel, Thibault -- Durkin, Thomas P -- Menzaghi, Frederique -- Bontempi, Bruno -- New York, N.Y. -- Science. 2004 Jul 2;305(5680):96-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratoire de Neurosciences Cognitives, CNRS UMR 5106, Universite de Bordeaux 1, Avenue des Facultes, 33405 Talence, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15232109" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain Mapping
;
GAP-43 Protein/metabolism
;
Gene Expression Regulation
;
Genes, Immediate-Early
;
Gyrus Cinguli/*physiology
;
Immediate-Early Proteins/metabolism
;
Lidocaine/pharmacology
;
Male
;
Memory/drug effects/*physiology
;
Mental Recall
;
Mice
;
Mice, Inbred C57BL
;
Neocortex/*physiology
;
Nerve Net/physiology
;
Neuronal Plasticity
;
Neurons/physiology
;
Parietal Lobe/physiology
;
Prefrontal Cortex/*physiology
;
Synapses/physiology
;
Time Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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