ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
The present study was designed to investigate whether porous titanium (Ti) havingYoung’s modulus similar to bone has osteoconductive characteristics in rat critical-sized calvarialbone defect. The effect of coating by octacalcium phosphate (OCP) was also examined. OCP isknown as a precursor of initial mineral crystals of biological apatite in bones and teeth. Ti powder wasprepared by plasma rotating electrode process in an Ar atmosphere. Then, porous Ti disks, 8 mm indiameter with 1 mm thick, were obtained using the particles ranging from 300 to 500 +m, by sinteringat 1573 K without applied pressure. The disks had about 35 vol% in porosity and about 10 GPa inYoung’s modulus which corresponds to that of human cortical bone. Newly formed bone wasobserved so as to fill the pore up at 12 weeks, confirming the ability to conduct the ingrowths of thebone tissue. Although in vitro study showed that proliferation of mouse bone marrow stromal ST-2cells was inhibited on the dishes coated by OCP rather than the control dish, OCP coating on porousTi seemed to stimulate the bone formation in vivo. Taken together, it seems likely that porous Tihaving Young’s modulus similar to bone shows osteoconductive characteristics to conduct boneingrowths. OCP could be a potential coating agent to assist bone regeneration on porous Ti
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.951.pdf
Permalink