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  • 1
    Electronic Resource
    Electronic Resource
    Regelung nichtlinearer Strecken mittels linearer parameterveränderlicher Systeme (1999)
    Springer
    Electrical engineering 82 (1999), S. 59-70 
    Details
    ISSN: 1432-0487
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Description / Table of Contents: Contents We present a new approach to reduce the controller design for general nonlinear plants to Linear parameter-varying systems (LPV-systems). Therefore we model a class of nonlinear systems as LPV system via a nonlinear state-transformation. This practise allows us to use LPV-controller design methods. In this article we apply Self-scheduled H ∞ -control. The proposed conception will be demonstrated on an example.
    Notes: Übersicht Es wird vorgeschlagen, den Reglerentwurf für nichtlineare Strecken auf die Synthese an Linearen parameterveränderlichen Systemen (LPV-Systemen) zurückzuführen. Dies ist dann möglich, wenn es gelingt ein nichtlineares Streckenmodell so umzuformen, daß es als LPV-System betrachtet werden kann. Diese Umformung geschieht hier mit Hilfe einer nichtlinearen Zustandstransformation. Als LPV-Entwurfsverfahren wird die Self-scheduled H ∞ -Regelung herangezogen. Die Demonstration der Strategie erfolgt an einem Beispiel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002020050077
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  • 2
    Electronic Resource
    Electronic Resource
    A polymorphism but no mutations in the GADD45 gene in breast cancers (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 543-547 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The p53 gene product is part of a pathway regulating growth arrest at the G1 checkpoint of the cell cycle. Mutation of other components of this pathway, including the products of the ataxia telangiectasia (AT), GADD45, mdm2, and p21WAF1/CIP1 genes may have effects comparable to mutations in the p53 gene. The GADD45 gene is induced by ionizing radiation and several DNA-damaging xenobiotics. Induction requires the binding of wild-type p53 to an evoulutionarily highly conserved putative intronic p53 binding site in intron 3 of GADD45. We recently analyzed the entire coding region of the p53 gene in primary breast cancers of Midwestern white women and found 21 mutations among 53 tumors (39,6%). We now have shown by direct sequencing that there are no mutations in the intronic p53 binding site of the GADD45 gene in any of the 53 primary breast cancers and no mutations in the entire coding region of the GADD45 gene in a subset of 26 consecutive tumors (12 with p53 mutation and 14 without p53 mutation). The only sequence variation detected was a common polymorphism in intron 3. The absence of mutations in the GADD45 gene, including the putative p53-binding intronic site, suggests that this gene is not a frequent target of mutations in breast cancer. Although mutations of the p53 gene have been studied in a wide spectrum of human cancers, GADD45 has not been examined in any tumor or cell line to the best of our knowledge. Our results raise the possibility that mutation of the GADD45 gene alone is not functionally equivalent to loss of wild-type p53 activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02267084
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  • 3
    Electronic Resource
    Electronic Resource
    A polymorphism but no mutations in the GADD45 gene in breast cancers (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 543-547 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The p53 gene product is part of a pathway regulating growth arrest at the G1 checkpoint of the cell cycle. Mutation of other components of this pathway, including the products of the ataxia telangiectasia (AT), GADD45, mdm2, and p21WAF1/CIP1 genes may have effects comparable to mutations in the p53 gene. The GADD45 gene is induced by ionizing radiation and several DNA-damaging xenobiotics. Induction requires the binding of wild-type p53 to an evoulutionarily highly conserved putative intronic p53 binding site in intron 3 of GADD45. We recently analyzed the entire coding region of the p53 gene in primary breast cancers of Midwestern white women and found 21 mutations among 53 tumors (39,6%). We now have shown by direct sequencing that there are no mutations in the intronic p53 binding site of the GADD45 gene in any of the 53 primary breast cancers and no mutations in the entire coding region of the GADD45 gene in a subset of 26 consecutive tumors (12 with p53 mutation and 14 without p53 mutation). The only sequence variation detected was a common polymorphism in intron 3. The absence of mutations in the GADD45 gene, including the putative p53-binding intronic site, suggests that this gene is not a frequent target of mutations in breast cancer. Although mutations of the p53 gene have been studied in a wide spectrum of human cancers, GADD45 has not been examined in any tumor or cell line to the best of our knowledge. Our results raise the possibility that mutation of the GADD45 gene alone is not functionally equivalent to loss of wild-type p53 activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050090
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  • 4
    Electronic Resource
    Electronic Resource
    Absence of somatic mosaicism in 17 families with hemophilia B: an analysis with a sensitivity 10- to 1000-fold greater than that of sequencing gels (1996)
    Springer
    Human genetics 〈Berlin〉 98 (1996), S. 539-545 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Most estimates of germ-line mosaicism have been derived from families in which there has been transmission of a mutated allele to two or more children by an unaffected individual. Previously, analyses for somatic mosaicism detected five such individuals by PCR-based sequencing and haplotype analysis at a sensitivity of approximately 1 mutant per 10 wild-type alleles. To determine whether mutations that occur later in embryogenesis also give rise to somatic mosaicism, we analyzed leukocyte DNA from 17 individuals in whom a mutation in the factor IX gene was known to have originated. Methods capable of detecting 1 mutant allele in 100–10 000 were utilized, and no further examples of somatic mosaicism were detected. If confirmed by future studies, the paucity of somatic mosaicism with mutant:wild-type allele frequencies ranging from 1:10 to 1:1000 (relative to the 11% of somatic mosaicism detected with mutant:wild-type allele frequencies of 1:1 to 1:10) may reflect a higher mutation rate and/or germ-line lineage allocation very early in embryogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050256
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  • 5
    Electronic Resource
    Electronic Resource
    Diffusion of slot injected drag-reducing polymer solution in a LEBU modified turbulent boundary layer (1992)
    Springer
    Experiments in fluids 12 (1992), S. 181-188 
    Details
    ISSN: 1432-1114
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The effects of a tandem set of large eddy breakup (LEBU) devices on the diffusion of drag-reducing polymer solution and of water injected into a turbulent boundary layer flow have been studied. Laser Doppler velocimeter measurements were taken in the LEBU modified boundary layer with and without polymer injection. A laser-induced fluorescence technique was used to examine the development of concentration profiles of the injected fluids with increasing distance from the injection slot for a range of injection rates. The diffusion rate of water, a passive contaminant, was diminished by the LEBU devices over a distance of only 10 to 15 boundary layer thicknesses before returning to the case of an unmodified flow; whereas the devices did have a major effect on the diffusion of polymer over the entire streamwise distance studied compared to the case of an unmodified flow. Large reductions of turbulent normal and shear stresses were observed downstream of the devices, especially with polymer injection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00188257
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of air flow rate, lime amendments, and chemical soil properties on the volatilization of ammonia from fertilizers applied to sandy soils (1996)
    Springer
    Biology and fertility of soils 21 (1996), S. 53-60 
    Details
    ISSN: 1432-0789
    Keywords: Urea ; Ammoniacal fertilizers ; Ammonia volatilization ; Sandy soils ; pH ; Ammonia loss model ; Air flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract NH3 volatilization from surface-applied urea, diammonium phosphate (DAP), and calcium ammonium nitrate (CAN) was measured with chambers through which air was drawn continuously. Two sandy soils and two sandy loam soils, which had been treated with and without time for the last 25 years, were used for the experiments. The accumulated NH3 loss from CAN applied to an unlimed sandy soil was linearly related to time. For the other treatments the accumulated loss was exponentially related to time. The NH3 loss was exponentially related to the maximum soil pH of the fertilizer-amended soil, and was inversely related to the content of exchangeable H+. Due to the low cation exchange capacity of these light-textured soils the NH3 loss was not reduced as the soil CEC increased. The maximum pH after soil amendment was related to soil pH. Therefore, a model is proposed that relates the NH3 loss solely to fertilizers and soil pH. The NH3 loss was less than 5% from CAN, about 20% from DAP, and about 30% from urea, with the insignificant loss from urea applied to the unlimed sandy soil excluded. The NH3 loss from surface-applied DAP was related to the air flow rate and a transfer coefficient (K a) was estimated. K a increased exponentially with the flow rate. At a flow rate above 3.9 liters min−1 (20 volume exchanges min−1) no further increase was seen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335993
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  • 7
    Electronic Resource
    Electronic Resource
    Micrometeorological mass balance technique for measuring CH4 emission from stored cattle slurry (1997)
    Springer
    Biology and fertility of soils 24 (1997), S. 442-444 
    Details
    ISSN: 1432-0789
    Keywords: Key words Greenhouse effect ; Methane ; Cattle slurry ; Diurnal variations ; Arrhenius equation ; Micrometerorological CH4 emission technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Methane (CH4) emissions from stored slurry were successfully measured by a micrometeorological mass balance technique. Emissions during autumn to late winter ranged from 2 to 100kgCH4-Cha–1day–1. Diurnal variations of CH4 emissions were investigated by measuring emissions at several times during the day, correlated with slurry temperatures at 10cm depth and successfully modelled with the Arrhenius equation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003740050270
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  • 8
    Electronic Resource
    Electronic Resource
    A simple biomonitor for measuring ammonia deposition in rural areas (1988)
    Springer
    Biology and fertility of soils 6 (1988), S. 61-64 
    Details
    ISSN: 1432-0789
    Keywords: Ammonia emission ; Ammonia absorption ; Nitrogen cycle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Knowledge of the contribution of NH3 to the total deposition of N in rural areas is sparse, because the determination of NH3 deposition is costly and labour-intensive. A simple biomonitor consisting of barley plants grown in pots with an inert growth medium is therefore proposed for estimating total N deposition, including NH3. The rise in total N of the plant-soil system reflects the deposition. The biomonitor was tested near a dairy farm. Different N contents in the green biomass reflected differences in deposition, and the deposition correlated very well with NH3 levels in the area and in two background stations. The biomonitors were placed above the crop, the measurements thus representing total N at the edge of a plant community. In 1 month the deposition in the NH3 plume was 8 kg N ha−1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257922
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  • 9
    Electronic Resource
    Electronic Resource
    Porphyrin derivatives having physical and chemical characteristics similar to those of the active components of hematoporphyrin derivative and with very strong photosensitizing effects
    Amsterdam : Elsevier
    Journal of Photochemistry and Photobiology B: Biology 1 (1987), S. 241-246 
    Details
    ISSN: 1011-1344
    Keywords: Hematoporphyrin ethers ; Photofrin II ; chromatography ; photosensitization. ; tumour localization
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/1011-1344(87)80031-3
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  • 10
    Electronic Resource
    Electronic Resource
    Introduction of a UV-damaged replicon into a recipient cell is not a sufficient condition to produce an SOS-inducing signal
    Amsterdam : Elsevier
    Mutation Research/DNA Repair 254 (1991), S. 107-117 
    Details
    ISSN: 0921-8777
    Keywords: Nature of SOS signal ; OriC ; OriF ; RecA protein activation ; Replication
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-8777(91)90001-6
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