ISSN:
1573-8221
Keywords:
thyroid hormones
;
metaphase chromosomes
;
interphase nucleus
;
sitespecific region
;
receptor
;
triiodothyronine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Thyroid hormones labeled with125I are localized on structures of the interphase nucleus and metaphase chromosomes of fibroblasts from 8–10-week human embryos in culture. Meanwhile, although labeled thyroid hormones are present in interphase nuclei of HeLa cells, by contrast with normal cells they are not accepted by their metaphase chromosomes. It is suggested on the basis of the results that the acceptor region of the genome of HeLa cells during transformation have lost their ability to bind their own receptor complexes with thyroid hormones.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00804790
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