Publication Date:
2019
Description:
〈sec〉〈st〉Synopsis〈/st〉〈p〉〈textbox textbox-type="graphic"〉〈p〉〈inline-fig〉〈/inline-fig〉〈/p〉〈/textbox〉〈/p〉
〈p〉Ubiquitin-dependent membrane protein degradation is thought to occur primarily via ERAD or ESCRT pathways. Endosome and Golgi-associated degradation (EGAD) of membrane proteins from post-ER compartments represents a novel mechanisms contributing to proteostasis and lipid homeostasis in 〈i〉S. cerevisiae〈/i〉.〈/p〉
〈p〉 〈l type="unord"〉〈li〉〈p〉EGAD selectively extracts membrane proteins from Golgi and endosomes for degradation by cytosolic proteases.〈/p〉〈/li〉
〈li〉〈p〉Orm2, a repressor of sphingolipid synthesis, represents the first endogenous EGAD substrate.〈/p〉〈/li〉
〈li〉〈p〉Cdc48/VCP extracts Orm2 from membranes following its ubiquitination by the Dsc ubiquitin ligase complex.〈/p〉〈/li〉
〈li〉〈p〉EGAD-dependent Orm2 degradation is essential for a controlled de-repression of sphingolipid synthesis.〈/p〉〈/li〉〈/l〉 〈/p〉〈/sec〉
Print ISSN:
0261-4189
Electronic ISSN:
1460-2075
Topics:
Biology
,
Medicine
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