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  • 1
    Publication Date: 2018-03-06
    Description: Motivation The traditional view of cancer evolution states that a cancer genome accumulates a sequential ordering of mutations over a long period of time. However, in recent years it has been suggested that a cancer genome may instead undergo a one-time catastrophic event, such as chromothripsis , where a large number of mutations instead occur simultaneously . A number of potential signatures of chromothripsis have been proposed. In this work, we provide a rigorous formulation and analysis of the ‘ability to walk the derivative chromosome’ signature originally proposed by Korbel and Campbell. In particular, we show that this signature, as originally envisioned, may not always be present in a chromothripsis genome and we provide a precise quantification of under what circumstances it would be present. We also propose a variation on this signature, the H/T alternating fraction , which allows us to overcome some of the limitations of the original signature. Results We apply our measure to both simulated data and a previously analyzed real cancer dataset and find that the H/T alternating fraction may provide useful signal for distinguishing genomes having acquired mutations simultaneously from those acquired in a sequential fashion. Availability and implementation An implementation of the H/T alternating fraction is available at https://bitbucket.org/oesperlab/ht-altfrac . Contact loesper@carleton.edu Supplementary information Supplementary dataSupplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-07-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Escoffier, J -- Malyon, A -- Morin, S -- Raphael, S -- New York, N.Y. -- Science. 1980 Jul 18;209(4454):340.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17747794" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    RAND Corporation
    Publication Date: 2024-03-29
    Description: This report analyzes the National Guard’s centrality to American national security, the idea that it prevents the United States from fighting controversial foreign wars, and its claim to embody the citizen soldier. It concludes that there are increasing tensions among these three ideals and that as the Guard has become an increasingly important tool of American national security, it has lost some of the attributes of the citizen soldier.
    Keywords: Technology ; History ; Political Science ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWK Military and defence strategy ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTM Military engineering
    Language: English
    Format: image/jpeg
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  • 4
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    Dordrecht : Periodicals Archive Online (PAO)
    Synthese. 37:2 (1978:feb.) 117 
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Synthese 〈Dordrecht〉 37 (1978), S. 117-216 
    ISSN: 1573-0964
    Source: Springer Online Journal Archives 1860-2000
    Topics: Natural Sciences in General , Philosophy
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 271 (1978), S. 401-401 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR,-This is a reply to a number of recent letters (Nature 270, 381-384 and 658; 1977) attacking our article (Zahler & Sussmann Nature 269, 759; 1977) on applied catastrophe theory. Many of these cite applications in the physical sciences to rebut our criticism; but as we were careful to state ...
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 269 (1977), S. 759-763 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Several representative attempts to apply catastrophe theory to biological and social science problems turn out on close analysis to be characterised by incorrect reasoning, far-fetched assumptions, erroneous consequences, and exaggerated claims. Catastrophe theory seems to have made no significant ...
    Type of Medium: Electronic Resource
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  • 8
    Publication Date: 2021-05-25
    Description: On active volcanoes, ambient noise-based seismic interferometry can be a very useful monitoring tool as it allows to detect very slight variations in seismic velocity associated with magma transport towards the surface. In this work, we performed the autocorrelation of ambient seismic noise recorded at Mt. Etna volcano, by three stations located close to the active summit craters, during April 2013 - October 2014. Such an interval was chosen because of the number and variety of eruptions. In place of the classical cross-correlation, we implemented the phase cross-correlation of each component with itself, which does not require normalization of the signals. The detected seismic velocity variations were very consistent for all three stations throughout the study period, mainly ranging between 0.3 and -0.2%, and were time-related to both sequences of paroxysmal eruptions and more effusive activities. In particular, we observed seismic velocity decreases accompanying paroxysmal eruptions, suggesting an intense pressurization within the plumbing system, which created an area of extensional strain with crack openings. It is worth noting that classical cross-station approach failed to detect seismic velocity changes related to volcano activity. In addition, seismic velocity variations over time were integrated with ground deformation data recorded by GPS stations and volcanic tremor centroid locations. Finally, we showed that, although the investigated frequency band (1-2 Hz) contains most of the volcanic tremor energy, our results did not indicate a particular contamination of seismic velocity variation measurements by variations of tremor sources.
    Description: Published
    Description: 5V. Dinamica dei processi eruttivi e post-eruttivi
    Description: JCR Journal
    Keywords: volcano monitoring, ambient seimic noise, autocorrelation, Mt. Etna volcano, seismic noise interferometry, volcanic tremor, seismic velocity variation
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 9
    Publication Date: 2021-11-26
    Description: During the COVID-19 pandemic, most countries put in place social interventions, restricting the mobility of citizens, to slow the spread of the epidemic. Italy, the first European country severely impacted by the COVID-19 outbreak, applied a sequence of progressive restrictions to reduce human mobility from the end of February to mid- March 2020. Here, we analysed the seismic signatures of these lockdown measures in densely populated eastern Sicily, characterized by the presence of a permanent seismic network used for earthquake and volcanic monitoring. We emphasize how the anthropogenic seismic noise decrease is visible even at stations located in remote areas (Etna and Aeolian Islands) and that the amount of this reduction (reaching 50 %–60 %), its temporal pattern and spectral content are strongly station-dependent. Concerning the latter, we showed that on average the frequencies above 10 Hz are the most influenced by the anthropogenic seismic noise.We found similarities between the temporal patterns of anthropogenic seismic noise and human mobility, as quantified by the mobilephone- derived data shared by Google, Facebook and Apple, as well as by ship traffic data. These results further confirm how seismic data, routinely acquired worldwide for seismic and volcanic surveillance, can be used to monitor human mobility too.
    Description: Published
    Description: 299–317
    Description: 1T. Struttura della Terra
    Description: JCR Journal
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 10
    Publication Date: 2022-06-09
    Description: Human activity causes vibrations that propagate into the ground as high-frequency seismic waves. Measures to mitigate the coronavirus disease 2019 (COVID-19) pandemic caused widespread changes in human activity, leading to a months-long reduction in seismic noise of up to 50%. The 2020 seismic noise quiet period is the longest and most prominent global anthropogenic seismic noise reduction on record. Although the reduction is strongest at surface seismometers in populated areas, this seismic quiescence extends for many kilometers radially and hundreds of meters in depth. This quiet period provides an opportunity to detect subtle signals from subsurface seismic sources that would have been concealed in noisier times and to benchmark sources of anthropogenic noise. A strong correlation between seismic noise and independent measurements of human mobility suggests that seismology provides an absolute, real-time estimate of human activities.
    Description: Published
    Description: 1338–1343
    Description: 3T. Sorgente sismica
    Description: JCR Journal
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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