Publication Date:
2012-08-11
Description:
During development of the mammalian cerebral cortex, radial glial cells (RGCs) generate layer-specific subtypes of excitatory neurons in a defined temporal sequence, in which lower-layer neurons are formed before upper-layer neurons. It has been proposed that neuronal subtype fate is determined by birthdate through progressive restriction of the neurogenic potential of a common RGC progenitor. Here, we demonstrate that the murine cerebral cortex contains RGC sublineages with distinct fate potentials. Using in vivo genetic fate mapping and in vitro clonal analysis, we identified an RGC lineage that is intrinsically specified to generate only upper-layer neurons, independently of niche and birthdate. Because upper cortical layers were expanded during primate evolution, amplification of this RGC pool may have facilitated human brain evolution.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287277/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287277/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Franco, Santos J -- Gil-Sanz, Cristina -- Martinez-Garay, Isabel -- Espinosa, Ana -- Harkins-Perry, Sarah R -- Ramos, Cynthia -- Muller, Ulrich -- MH078833/MH/NIMH NIH HHS/ -- NS046456/NS/NINDS NIH HHS/ -- NS060355/NS/NINDS NIH HHS/ -- R01 NS046456/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2012 Aug 10;337(6095):746-9. doi: 10.1126/science.1223616.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dorris Neuroscience Center and Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22879516" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Lineage
;
Cell Proliferation
;
Cells, Cultured
;
Cerebral Cortex/*cytology/embryology
;
Homeodomain Proteins/genetics
;
Mice
;
Neural Stem Cells/*cytology/physiology
;
*Neurogenesis
;
Neuroglia/*cytology
;
Neurons/*cytology/physiology
;
Recombination, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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