Publication Date:
1999-11-13
Description:
The factors required for the generation of memory CD4 T cells remain unclear, and whether there is a continuing requirement for antigen stimulation is critical to design of vaccine strategies. CD4 effectors generated in vitro from naive CD4 T cells of mice efficiently gave rise to small resting memory cells after transfer to class II-deficient hosts, indicating no requirement for further antigen or class II recognition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Swain, S L -- Hu, H -- Huston, G -- New York, N.Y. -- Science. 1999 Nov 12;286(5443):1381-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biomedical Research Laboratories, Trudeau Institute, 100 Algonquin Avenue, Saranac Lake, NY 12983, USA. sswain@northnet.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10558997" target="_blank"〉PubMed〈/a〉
Keywords:
Adoptive Transfer
;
Animals
;
Cell Division
;
Cytokines/biosynthesis
;
Histocompatibility Antigens Class II/*immunology
;
Immunization
;
*Immunologic Memory
;
Mice
;
Mice, Inbred C57BL
;
Mice, Knockout
;
Mice, Transgenic
;
Receptors, Antigen, T-Cell/immunology
;
T-Lymphocyte Subsets/cytology/*immunology
;
Th1 Cells/cytology/*immunology
;
Th2 Cells/cytology/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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