Publication Date:
2009-11-11
Description:
Genetic changes contributing to phenotypic differences within or between species have been identified for a handful of traits, but the relationship between alleles underlying intraspecific polymorphism and interspecific divergence is largely unknown. We found that noncoding changes in the tan gene, as well as changes linked to the ebony gene, contribute to pigmentation divergence between closely related Drosophila species. Moreover, we found that alleles linked to tan and ebony fixed in one Drosophila species also contribute to variation within another species, and that multiple genotypes underlie similar phenotypes even within the same population. These alleles appear to predate speciation, which suggests that standing genetic variation present in the common ancestor gave rise to both intraspecific polymorphism and interspecific divergence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wittkopp, Patricia J -- Stewart, Emma E -- Arnold, Lisa L -- Neidert, Adam H -- Haerum, Belinda K -- Thompson, Elizabeth M -- Akhras, Saleh -- Smith-Winberry, Gabriel -- Shefner, Laura -- New York, N.Y. -- Science. 2009 Oct 23;326(5952):540-4. doi: 10.1126/science.1176980.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA. wittkopp@umich.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19900891" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Animals
;
Animals, Genetically Modified
;
Base Sequence
;
Chromosomal Proteins, Non-Histone/*genetics/metabolism
;
Crosses, Genetic
;
DNA-Binding Proteins/*genetics/metabolism
;
Drosophila/classification/*genetics/growth & development/metabolism
;
Drosophila Proteins/*genetics/metabolism
;
Female
;
Gene Expression
;
Gene Expression Regulation
;
Genes, Insect
;
Genetic Speciation
;
Genotype
;
Introns
;
Male
;
Molecular Sequence Data
;
Phenotype
;
Pigmentation/*genetics
;
*Polymorphism, Genetic
;
Quantitative Trait Loci
;
Species Specificity
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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