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  • 1
    Electronic Resource
    Electronic Resource
    RNA-templated DNA repair (2007)
    [s.l.] : Nature Publishing Group
    Nature 448 (2007), S. 1076-1076 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Nature 447, 338–341 (2007) In Figure 1, the column header indicating the repair frequencies should read “Repair frequency (Leu+) × 10-7” rather than “Repair frequency ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature06114
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  • 2
    Electronic Resource
    Electronic Resource
    RNA-templated DNA repair (2007)
    [s.l.] : Nature Publishing Group
    Nature 447 (2007), S. 338-341 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] RNA can act as a template for DNA synthesis in the reverse transcription of retroviruses and retrotransposons and in the elongation of telomeres. Despite its abundance in the nucleus, there has been no evidence for a direct role of RNA as a template in the repair of any chromosomal DNA ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05720
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  • 3
    Electronic Resource
    Electronic Resource
    In vivo site-directed mutagenesis using oligonucleotides (2001)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 19 (2001), S. 773-776 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Functional characterization of the genes of higher eukaryotes has been aided by their expression in model organisms and by analyzing site-specific changes in homologous genes in model systems such as the yeast Saccharomyces cerevisiae. Modifying sequences in yeast or other organisms such that no ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/90837
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  • 4
    Electronic Resource
    Electronic Resource
    Sunlight-induced Killing in Saccharomyces cerevisiae (1970)
    [s.l.] : Nature Publishing Group
    Nature 226 (1970), S. 377-378 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In what follows I use uvs 93 to indicate the third identified mutant allele of the uvs 9 locus, and phr 1 forthe first identified mutant allele of the phr 1 locus. Capital letters signify the wild type, uvs 93 mutants are considered2 to be defective in excision-repair, a stepwise process of removal ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/226377a0
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  • 5
    Electronic Resource
    Electronic Resource
    Repeat expansion : all in flap? (1997)
    [s.l.] : Nature Publishing Group
    Nature genetics 16 (1997), S. 116-118 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Expansion of repeated DNA sequences comprises a unique category of human mutations that transfixes geneticists and has inspired numerous studies of human triple-repeat disorders and exploration of their genesis in model systems1–3. But while the expansions themselves have been characterized ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng0697-116
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  • 6
    Electronic Resource
    Electronic Resource
    Cadmium is a mutagen that acts by inhibiting mismatch repair (2003)
    [s.l.] : Nature Publishing Group
    Nature genetics 34 (2003), S. 326-329 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Most errors that arise during DNA replication can be corrected by DNA polymerase proofreading or by post-replication mismatch repair (MMR). Inactivation of both mutation-avoidance systems results in extremely high mutability that can lead to error catastrophe. High mutability and the likelihood of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1172
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  • 7
    Electronic Resource
    Electronic Resource
    Genes required for ionizing radiation resistance in yeast (2001)
    [s.l.] : Nature Publishing Group
    Nature genetics 29 (2001), S. 426-434 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The ability of Saccharomyces cerevisiae to tolerate ionizing radiation damage requires many DNA-repair and checkpoint genes, most having human orthologs. A genome-wide screen of diploid mutants homozygous with respect to deletions of 3,670 nonessential genes revealed 107 new loci that influence ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng778
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  • 8
    Electronic Resource
    Electronic Resource
    Heterogeneity and maintenance of centromere plasmid copy number inSaccharomyces cerevisiae (1990)
    Springer
    Chromosoma 99 (1990), S. 281-288 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We developed a novel approach to quantitate the heterogeneity of centromere number in yeast, and the cellular capacity for excess centromeres. Small circular plasmids were constructed to contain theCUP1 metallothionein gene,ARS1 (autonomously replicating sequence) and a conditionally functional centromere (GAL1–GAL10 promoter controlled centromere). TheCUP1 gene provided a gene dosage marker, and therefore a genetic determinant of plasmid copy number. Growth of cells on glucose is permissive for centromere function, while growth on galactose renders the centromere nonfunctional and the plasmids are segregated in an asymmetric fashion. We identified “lines” of cells containing increased numbers of plasmids after transformation. Cell lines containing as many as five to ten active centromeres are stably maintained in the absence of genetic selection. Thus haploid yeast cells can tolerate a 50% increase in their centromere number without affecting progression through the cell cycle. This system provides the opportunity to address issues of specific cellular controls on centromere copy number.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731704
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  • 9
    Electronic Resource
    Electronic Resource
    The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control (1976)
    Springer
    Molecular genetics and genomics 143 (1976), S. 119-129 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary With the use of neutral sucrose sedimentation techniques, the size of unirradiated nuclear DNA and the repair of double-strand breaks induced in it by ionizing radiation have been determined in both wild-type and homozygous rad52 diploids of the yeast Saccharomyces cerevisiae. The number average molecular weight of unirradiated DNA in these experiments is 3.0×108±0.3 Daltons. Double-strand breaks are induced with a frequency of 0.58×10-10 per Daltonkrad in the range of 25 to 100 krad. Since repair at low doses is observed in wild-type but not homozygous rad52 strains, the corresponding rad52 gene product is concluded to have a role in the repair process. Cycloheximide was also observed to inhibit repair to a limited extent indicating a requirement for protein synthesis. Based on the sensitivity of various mutants and the induction frequency of double-strand breaks, it is concluded that there are 1 to 2 double-strand breaks per lethal event in diploid cells incapable of repairing these breaks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00266917
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  • 10
    Electronic Resource
    Electronic Resource
    Genetic repair and the synthesis of nitrate reductase in Ustilago maydis after UV irradiation (1971)
    Springer
    Molecular genetics and genomics 111 (1971), S. 171-184 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The ability of UV-sensitive (uvs -) and wild type (uvs +) strains of Ustilago maydis to synthesize the inducible enzyme nitrate reductase (NR) was examined following UV-exposure. Low doses of UV-irradiation prior to induction inhibit to a greater degree the first appearance of NR in uvs - as compared to uvs + strains; in addition, the exponentially increasing rates of NR synthesis are much less in the uvs - strains. It is concluded that the damage is primarily pyrimidine dimers in the DNA, since the UV-induced effects are largely removed by photoreactivation. At all but the lowest dose, at least one dimer on the average appears to be induced per functional strand of the nitrate reductase gene. If cells are irradiated after being suspended in NR inducing medium. enzyme synthesis is temporarily stopped or considerably reduced indicating that the mRNA has a short half-life and that transcription is inhibited. However, it resumes within 20 min after exposure which suggests that alteration or removal of damage is very rapid. Unrepaired or improperly repaired dimer regions lead to the production of altered enzyme as shown by the presence of enzyme cross reacting material and the heat lability of NR in crude cell extracts. It is proposed that the synthesis of altered enzyme may be due in part to transcription past unrepaired or improperly repaired dimer regions in the nitrate reductase gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00267791
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