ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
From the rhizomes of american Podophyllum peltatum L. it was possible to isolate and characterize four lignan glucosides with anti-mitotic activity: podophyllotoxin-β-D-glucoside (IX), β-peltatin-β-D-glucoside (XI), 4′-demethylpodophyllotoxin-β-D-glucoside (X) and α-peltatin-β-u-glucoside (XII). The constitution of β-peltatin-β-D- glucoside was deduced from the fact that enzymatic cleavage with emulsin yielded D-glucose and the already known β-peltatin. α-Peltatin-β-D-glucoside, the first native glucoside of podophyllum t o be isolated in crystalline form, breaks down to D-glucose and α-peltatin on hydrolysis with emulsin. The position of the sugar component in 4′- demethylpodophyllotoxin-β-D-glucoside and in α-peltatin-β-D-glucoside could be determined by methylation to podophyllotoxin-β-D- glucoside and β-peltatin-β-D-glucoside.Distribution chromatography of the lignan glucosides on columns of silicagel proved a reliable analytical procedure. It could be used both as a test of purity and for assaying enriched fractions and crude plant extracts.
Additional Material:
11 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19570400525
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