ISSN:
1573-4951
Keywords:
Cholecystokinin
;
CCK-A antagonists
;
Field-fit
;
Comparative molecular field analysis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary Comparative molecular field analysis (CoMFA) has been used as a three-dimensional quantitative structure-activity relationship (QSAR) method to correlate the affinities of several antagonists towards CCK-A receptors with their steric and electrostatic fields. In this publication, we describe, for the first time, a field-fit operation as an alignment technique. These results could serve as a guide for the design of new non-peptide antagonists.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00126214
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