ISSN:
1573-8221
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Ten phenothiazine derivatives were tested on mice for anticonvulsant potency at the time of their peak effect by the maximal electroshock seizure test (M. E. S.). Two clinically employed antiepileptic drugs —Luminal and diphenylhydantoin — were studied by the same technique. Their side effect (neurological toxicity) was investigated by the “rolling roller” method. All substances were found to abolish the tonic extensor phase of the maximal seizure. ED50, TD50 and protective indices (P. I.) for all drugs have been determined. Diphenylhydantoin, Luminal and Mepazine had the highest P. I.; protective indices of Propazine, Dinezine, chlorsubstituted analogs of Mepazine and Dinezine approached 1. Aminazine, Acepromazine, Étaperazine and Compazine were effective only in toxic doses. The suggestion is made that anticonvulsive action of phenothiazine derivatives differed from their general “central” effect.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00779653
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