ISSN:
1573-8221
Keywords:
opiate receptor agonists
;
DNA synthesis
;
cell division
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The effect of μ- and σ-opiate receptor agonists at 10 μg/kg on the processes of cell division in corneal and tongue epithelium of albino rats is studied using the method of autoradiography with3H-thymidine. The ligand of the μ-receptors causes the inhibition of DNA synthesis in corneal epithelium 4, 12, and 24 h later and lowers the mitotic index after 4 and 24 h. In contrast, in the tongue epithelium stimulation of the proliferative processes occurs. Ligand of the σ-receptors stimulates DNA synthesis in corneal epithelium after 12 and 24 h and cell division after 12 h. In the tongue epithelium DNA synthesis is activated after 4, 12, and 24 h and cell division after 12 h.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02444310
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